Publications by authors named "Alan S Nova"
Article Synopsis
- A regional network of ten hospitals implemented tenecteplase as the standard treatment for stroke in 2019, believing it would improve workflow and offer similar clinical outcomes compared to the traditional alteplase treatment.
- A study comparing 234 tenecteplase patients to 354 alteplase patients found that tenecteplase significantly reduced door-to-needle times and door-in-door-out times, while showing noninferior favorable and lower unfavorable outcomes.
- Overall, tenecteplase demonstrated a greater net benefit and lower average treatment costs compared to alteplase, suggesting it could be a more efficient option for stroke care.
Background: The mu opioid receptor (MOR) has previously been found to regulate ethanol-stimulated dopamine release under some, but not all, conditions. A difference in ethanol-evoked dopamine release between male and female mixed background C57BL/6J-129SvEv mice led to questions about its ubiquitous role in these effects of ethanol. Using congenic C57BL/6J MOR knockout (KO) mice and C57BL/6J mice pretreated with an irreversible MOR antagonist, we investigated the function of this receptor in ethanol-stimulated dopamine release.
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