Publications by authors named "Alan Roger Santos-Silva"

Objective: Evaluate the sociodemographic, clinical, and lifestyle characteristics at head and neck squamous cell carcinoma (HNSCC) diagnosis and their impact on overall survival (OS) across different anatomical sites.

Materials And Methods: A retrospective cohort study (2011-2021) at Instituto do Câncer do Estado de São Paulo, involving 3052 HNSCC patients. Survival analyses utilized the Kaplan-Meier method and Cox proportional hazard ratios with 95% confidence intervals, incorporating significant variables from univariate analysis.

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Background: Despite recent advancements, women still encounter significant challenges in various fields, including dentistry. However, the increasing interest in female participation in science acknowledges its fundamental role in the advancement of knowledge. This study aims to assess indicators of women's involvement in Brazilian research in the areas of Oral Pathology and Oral Medicine.

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  • This study focuses on the presence of human polyomaviruses (HPyV) in head and neck squamous cell carcinoma (SCC) samples, particularly examining the role of these viruses alongside traditional risk factors like smoking and alcohol.
  • Researchers analyzed 60 samples from different mouth and throat areas for four types of HPyV, finding a 60% positivity rate for JCPyV and low rates for MCPyV (5%) with no instances of BKPyV or TSPyV.
  • The study concluded that while JCPyV is commonly present in oral cavity and oropharyngeal SCC, no strong links to patient demographics or clinical characteristics were found, except for a notable association between JCP
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  • This systematic review investigated the connection between oncoviruses and head and neck cancers (HNC).
  • Researchers analyzed studies from five databases and assessed their reliability using established guidelines.
  • The findings revealed a significant relationship between certain oncoviruses, particularly HPV-16, HPV-18, and Epstein-Barr virus, and the development of HNC, while further research is needed on other viruses like human cytomegalovirus and Merkel Cell Polyomavirus.
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Objective: This study aimed to implement and evaluate a Deep Convolutional Neural Network for classifying myofibroblastic lesions into benign and malignant categories based on patch-based images.

Methods: A Residual Neural Network (ResNet50) model, pre-trained with weights from ImageNet, was fine-tuned to classify a cohort of 20 patients (11 benign and 9 malignant cases). Following annotation of tumor regions, the whole-slide images (WSIs) were fragmented into smaller patches (224 × 224 pixels).

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Aims: To develop a model capable of distinguishing carcinoma ex-pleomorphic adenoma from pleomorphic adenoma using a convolutional neural network architecture.

Methods And Results: A cohort of 83 Brazilian patients, divided into carcinoma ex-pleomorphic adenoma (n = 42) and pleomorphic adenoma (n = 41), was used for training a convolutional neural network. The whole-slide images were annotated and fragmented into 743 869 (carcinoma ex-pleomorphic adenomas) and 211 714 (pleomorphic adenomas) patches, measuring 224 × 224 pixels.

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The study of notable people as advocates for raising cancer awareness began in the latter decades of the 20th century. This research aimed to identify Pan-American notable people with head and neck cancer (HNC) and to explore senior health professionals' perspectives on communicating stories of notable patients with HNC to promote prevention. A cross-sectional survey was conducted using an online questionnaire designed in REDCap and administered to 32 senior health professionals with long-standing academic and clinical backgrounds in HNC.

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This study aimed to review the current body of literature on underexplored areas of photobiomodulation (PBM) for preventing and/or treating oral adverse events. Recent studies suggest that PBM may offer potential benefits in managing cancer-related toxicities other than oral mucositis. Nevertheless, further research to establish conclusive evidence is still missing.

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  • The study analyzes the characteristics of oral reactions to injectable soft tissue fillers, focusing on 151 patients, predominantly females averaging 54.9 years old.
  • Most reactions occurred about 20.4 months after injection, often presenting as painless nodules in the lips, with silicone and polymethylmetacrylate being the most common fillers used.
  • Key findings showed differences in reaction patterns based on the type of filler and highlighted the importance for clinicians to recognize these potential reactions when assessing asymptomatic nodules in older female patients.
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Objectives: To describe the historical evolution and dissemination of the Oral Medicine and Oral and Maxillofacial Pathology international societies and associations across the globe, and to provide insights into their significant contributions toward oral health promotion.

Study Design: This review was conducted in accordance with the JBI Scoping Review Methodology Group guidance. The reporting followed the Preferred Reporting Items for Systematic Reviews extension for Scoping Reviews (PRISMA-ScR).

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  • - A retrospective study was conducted to analyze 10 new cases of canalicular adenoma (CAD), reviewing medical records and histological slides from 2014-2024.
  • - The patients, primarily female with an average age of 61.2 years, presented mostly with solitary, asymptomatic nodules on the upper lip, and some experienced slight pain.
  • - The study emphasized distinct microscopic features of CAD and the utility of specific immunohistochemical markers in distinguishing CAD from other types of salivary gland tumors.
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  • Pierre Fauchard, known as the father of dentistry, made significant contributions to various dental fields, although his impact on oral medicine and maxillofacial pathology was previously overlooked.
  • This study aimed to uncover Fauchard’s work on oral diseases by analyzing both French and English sources, gathering information on diagnosed and treated conditions.
  • The research identified his contributions to diseases like scurvy, abscesses, and oral ulcers, highlighting his importance in diagnosing and treating various oral health issues relevant to modern dentistry.
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  • - The review focuses on the prevalence of oral diseases in palliative care patients, noting that oral alterations often result from the patients' underlying medical conditions and treatments, impacting their quality of life.
  • - A systematic evaluation of literature, including a meta-analysis of five studies involving over 2,500 patients, revealed significant rates of dental issues like caries (32%) and oral candidiasis (17%).
  • - The conclusion emphasizes the importance of early dental intervention and ongoing monitoring to improve comfort and prevent complications in patients receiving palliative care.
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  • A systematic review and meta-analysis evaluated the recurrence and progression risk of oral potentially malignant disorders (OPMD) and precancerous lesions after surgical treatments across various body sites.
  • Twelve studies were included, revealing that the variation in surgical protocols and unclear margin descriptions affected clinical outcomes, particularly for oral leukoplakia and anal intraepithelial neoplasia.
  • The analysis found no significant difference in recurrence risk between cold-knife and ablative treatments for oral leukoplakia and cervical intraepithelial neoplasia, highlighting the need for standardized surgical approaches.
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Objective: To assess the clinical scenarios in which nerve blocks are employed in the context of burning mouth syndrome (BMS).

Study Design: This scoping review followed the PRISMA-ScR. A protocol was generated on Open Science Framework.

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The objective of the present study was to investigate the frequency of oral leukoplakia and oral erythroplakia among young patients from three Brazilian reference centers in Oral and Maxillofacial Pathology. A retrospective study was carried out from 2011 to 2021 on 861 patients diagnosed with oral leukoplakia and oral erythroplakia. Demographic and clinicopathological data were evaluated.

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Cancer disclosure represents a complex healthcare dynamic. Physicians or caregivers may be prompted to withhold diagnosis information from patients. This study aims to comprehensively map and synthesize available evidence about diagnosis nondisclosure regarding head and neck cancer (HNC) patients.

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