Publications by authors named "Alan Perstin"
Quantifying the DNA-damaging Effects of FLASH Irradiation With Plasmid DNA.
Int J Radiat Oncol Biol Phys
June 2022
Article Synopsis
- The study aimed to explore a plasmid DNA nicking assay to measure the DNA damage from ultrahigh-dose-rate (FLASH) irradiation compared to conventional irradiation.
- Researchers used phantoms with plasmid DNA, irradiating them at different dose rates (conventional and FLASH) and analyzed the resulting DNA damage through gel electrophoresis to quantify single and double strand breaks.
- Findings showed that FLASH irradiation resulted in less DNA damage, with both relative biological effectiveness (RBE) measures being less than one, indicating a protective effect from FLASH compared to standard irradiation techniques.