Enhancing CRISPR/Cas gene editing through modulating cellular mechanical properties for cancer therapy.

Genome editing holds great potential for cancer treatment due to the ability to precisely inactivate or repair cancer-related genes. However, delivery of CRISPR/Cas to solid tumours for efficient cancer therapy remains challenging. Here we targeted tumour tissue mechanics via a multiplexed dendrimer lipid nanoparticle (LNP) approach involving co-delivery of focal adhesion kinase (FAK) siRNA, Cas9 mRNA and sgRNA (siFAK + CRISPR-LNPs) to enable tumour delivery and enhance gene-editing efficacy.

Technology and Reading: The Effects of CALL Glossing.

Studies of the effects of L1 glossing on L2 reading comprehension have shown varying results. The present meta-analytic study provides an update of the research of CALL glossing studies and examines key variables related to how CALL glossing can be effective. Findings revealed an overall effect size of .

Meta-Analysis and Computer-Mediated Communication.

Because of the use of human participants and differing contextual variables, research in second language acquisition often produces conflicting results, leaving practitioners confused and unsure of the effectiveness of specific treatments. This article provides insight into a recent seminal meta-analysis on the effectiveness of computer-mediated communication, providing further statistical evidence of the importance of its results. The significance of the study is examined by looking at the p values included in the references, to demonstrate how results can easily be misconstrued by practitioners and researchers.