Publications by authors named "Alan L Metz"
The amino sugar galactosamine (galN) induces alterations in the hepatic uridine nucleotide pool and has been widely used as a model of human viral hepatitis. Histopathological and clinical chemistry analyses of a cohort of rats following administration of galN revealed extreme interindividual variability in the extent of the toxic response which enabled classification of 'responder' and 'non-responder' phenotypes. An integrative metabolic profiling approach was applied to characterize biomarkers of exposure to galN in urine, serum, feces and liver from responders and non-responders.
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- Hepatocellular vacuolation is tricky for doctors because different stuff can build up in liver cells and look similar under a microscope.
- Some common ways to tell them apart are not very sensitive and need special types of tissue samples.
- A new method using specific stains can help doctors see the differences more easily in liver tissue from rats and works better than older methods.