Publications by authors named "Alan Ki Chiang"
Repetitive transcranial magnetic stimulation (rTMS) has shown promise as an intervention for pain. An unexplored research question is whether the delivery of rTMS prior to pain onset might protect against a future episode of prolonged pain. The present study aimed to determine whether (1) 5 consecutive days of rTMS delivered prior to experimentally induced prolonged jaw pain has a prophylactic effect on future pain intensity and (2) whether these effects were accompanied by increases in corticomotor excitability (CME) and/or sensorimotor peak alpha frequency (PAF).
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- - The study aimed to validate a biomarker signature for chronic pain management, using measures called peak alpha frequency (PAF) and corticomotor excitability (CME), in a model induced by nerve growth factor injections in the jaw muscle.
- - A total of 150 participants experienced pain for up to 4 weeks post-injection, with EEG and TMS used to assess PAF and CME; machine learning models were developed to predict pain sensitivity based on these measures.
- - The analysis showed that logistic regression was extremely effective, achieving perfect classification in training and strong performance in testing, indicating the PAF/CME biomarker signature has great promise for clinical applications in pain assessment.
Transcranial magnetic stimulation (TMS) has been used to examine inhibitory and facilitatory circuits during experimental pain and in chronic pain populations. However, current applications of TMS to pain have been restricted to measurements of motor evoked potentials (MEPs) from peripheral muscles. Here, TMS was combined with electroencephalography (EEG) to determine whether experimental pain could induce alterations in cortical inhibitory/facilitatory activity observed in TMS-evoked potentials (TEPs).
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