Publications by authors named "Alan Jorge"
Article Synopsis
- Becker muscular dystrophy (BMD) is a less severe X-linked genetic disorder caused by mutations in the DMD gene, resulting in truncated dystrophin and affecting muscle function, particularly in the heart.
- Researchers created a rat model for BMD by deleting specific exons of the Dmd gene and evaluated the rats for functional and histopathological changes during their first year, finding moderate muscle damage and progressive heart disease.
- RNA sequencing of cardiac tissue revealed shared abnormalities in BMD and Duchenne muscular dystrophy (DMD) rats, pointing to issues with key proteins at cell junctions, which could help understand dystrophin's role in muscle and heart function, and pave the way for new treatments.
Background And Objectives: Bipolar disorder is a chronic condition affecting millions of people worldwide. Currently, there is some evidence to suggest that cannabis use during adolescence may be an environmental risk factor for its onset, however inconsistencies have been observed across the literature. Considering this, we aimed to assess whether early lifetime cannabis is associated with subsequent bipolar disorder in young adults between 18 and 22 years of age.
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