Management of hemolytic disease of the fetus and newborn relies on monitoring of maternal antibody titers, fetal ultrasound, and fetal middle cerebral artery peak systolic velocity studies and is generally treated by intrauterine transfusion (IUT). Few studies have explored fetal and neonate physiological responses to IUT. Our objective was to examine fetal erythropoietic response and to examine neonatal erythropoietic effects after treatment.
View Article and Find Full Text PDFObjective: To evaluate differences between fasting and nonfasting bile acid levels in asymptomatic and symptomatic pregnant women.
Methods: This is a report of two prospective cohort studies describing bile acid levels in the fasting and nonfasting state in pregnancy. The first cohort included asymptomatic women with singleton pregnancies.
Background: Single-dose levonorgestrel has been legally available over the counter in the United States without age restriction since 2013. The objective of this study was to discover if there are barriers to access and to determine if such barriers vary based on the gender of the person making the purchase.
Materials And Methods: A male and female caller contacted 146 Richmond, Virginia pharmacies listed on the Plan B One Step website.
Objective: The objective of the study was to examine the clinical impact of specific fetal monitoring-related practices during induced labor.
Study Design: This was a prospective, nonrandomized study.
Results: We studied 14,398 women undergoing oxytocin induction of labor.
Breslow and Holubkov (J Roy Stat Soc B 59:447-461 1997a) developed semiparametric maximum likelihood estimation for two-phase studies with a case-control first phase under a logistic regression model and noted that, apart for the overall intercept term, it was the same as the semiparametric estimator for two-phase studies with a prospective first phase developed in Scott and Wild (Biometrica 84:57-71 1997). In this paper we extend the Breslow-Holubkov result to general binary regression models and show that it has a very simple relationship with its prospective first-phase counterpart. We also explore why the design of the first phase only affects the intercept of a logistic model, simplify the calculation of standard errors, establish the semiparametric efficiency of the Breslow-Holubkov estimator and derive its asymptotic distribution in the general case.
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