Publications by authors named "Alan G Zhang"
Lymphangioleiomyomatosis (LAM) is a rare, progressive lung disease that predominantly affects women. LAM cells carry mutations, causing mTORC1 hyperactivation and uncontrolled cell growth. mTORC1 inhibitors stabilize lung function; however, sustained efficacy requires long-term administration, and some patients fail to tolerate or respond to therapy.
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- Tuberous sclerosis complex (TSC) and lymphangioleiomyomatosis (LAM) are diseases linked to mutations in TSC1 and TSC2, leading to the growth of tumors in various organs, especially affecting women’s lungs in the case of LAM.
- Recent research using single-cell RNA sequencing in LAM patients revealed that specific genes involved in sphingolipid biosynthesis were activated, with significant increases in key enzymes like acid ceramidase (ASAH1) in TSC2-null cells.
- Combining the enzyme inhibitor ARN14976 with rapamycin showed promise in reducing tumor growth and cell viability in experimental models, pointing toward new therapeutic strategies targeting abnormal sphingolipid pathways in TSC and