Publications by authors named "Alan G Chramiec"
Article Synopsis
- Researchers are exploring incomplete understanding of metastatic disease to improve cancer treatment, focusing on metastatic colonization and the limited options for post-surgery patients.
- An engineered bone marrow tissue model allows for studying how different cellular components affect tumor cell behavior and influence the growth of triple-negative breast cancer (TNBC).
- The model also shows that patient-derived tumor organoids can replicate the behavior of aggressive metastatic cells, aiding in research on personalized treatment and understanding cancer’s progression in specific niches.
Although the majority of patients with acute myeloid leukemia (AML) initially respond to chemotherapy, many of them subsequently relapse, and the mechanistic basis for AML persistence following chemotherapy has not been determined. Recurrent somatic mutations in DNA methyltransferase 3A (DNMT3A), most frequently at arginine 882 (DNMT3A), have been observed in AML and in individuals with clonal hematopoiesis in the absence of leukemic transformation. Patients with DNMT3A AML have an inferior outcome when treated with standard-dose daunorubicin-based induction chemotherapy, suggesting that DNMT3A cells persist and drive relapse.
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