Dental findings in a family with hyperparathyroidism-jaw tumor syndrome and a novel HRPT2 gene mutation.

Hyperparathyroidism-jaw tumor syndrome (HPT-JT) is an important diagnosis because of the possible involvement of other family members and risk of malignant disease. We report clinical and genetic studies in a previously undocumented Australian family with HPT-JT. The proband and his sister presented with bilateral or recurrent mandibular radiolucencies diagnosed histopathologically as cemento-ossifying fibromas.

Subacute cutaneous lupus erythematosus presenting in a child.

A 5-year-old girl presented in summer with an erythematous, scaly annular eruption in a malar distribution. She had no symptoms or signs of systemic lupus erythematosus. A diagnosis of subacute cutaneous lupus erythematosus was made on the basis of the clinical and histological features, positive anti-Ro antibody and a mildly elevated erythrocyte sedimentation rate.

Anaplastic carcinoma of the thyroid with sclerohyaline nodules.

Sclerohyaline nodules, resembling deposits of amyloid, were noted in 3 cases of anaplastic thyroid carcinoma (ATC). All 3 patients were elderly, and 2 had good outcomes. Histologically, the nodules were dispersed throughout typical areas of ATC and formed the dominant histologic feature in these areas.