Publications by authors named "Alan Donald"
Parkinson disease is a progressive neurodegenerative disease for which leucine-rich repeat kinase 2 (LRRK2 carriers) p.G2019S confers substantial genotypic and population attributable risk. With informed consent, we have recruited clinical data from 778 patients from Tunisia (of which 266 have LRRK2 parkinsonism) and 580 unaffected subjects.
View Article and Find Full Text PDFSTX6 rs1411478 is not associated with increased risk of Parkinson's disease.
Parkinsonism Relat Disord
May 2013
Article Synopsis
- A variant in the Syntaxin 6 gene (rs1411478) has been linked to progressive supranuclear palsy (PSP), but this study investigates its role in Parkinson's disease (PD).
- The research involved analyzing STX6 genetic variability in PD patients from diverse regions like Canada, Norway, Taiwan, and Tunisia, as well as looking for harmful mutations in families.
- The study found no pathogenic mutations in STX6 and did not find significant differences in the genetic profiles between PD patients and controls, suggesting that STX6 is not involved in PD susceptibility.
Background: People who are cognitively impaired not demented (CIND) can be at an increased risk for developing dementia, but little is known about the natural history of CIND in clinical settings.
Method: We examined the 2-year outcome of CIND subjects in the Canadian Cohort Study of Cognitive Impairment and Related Dementias.CIND was diagnosed when at least one positive item was endorsed on the DSM-III-R dementia criteria, but not all criteria were met.