Publications by authors named "Alan David Irvine"
Increased loss-of-function filaggrin gene mutation prevalence in atopic dermatitis patients across northern latitudes indicates genetic fitness: A systematic review and meta-analysis.
Casper Milde Khatib Amalie Wandel Klein-Petersen Amalie Thorsti Møller Rønnstad Alexander Egeberg Maria Oberländer Christensen Alan David Irvine
Exp Dermatol
July 2024
Article Synopsis
- Loss-of-function mutations in the filaggrin gene (FLG) are the strongest genetic risk factor for atopic dermatitis (AD), with a prevalence of 19.1% in AD patients compared to 5.8% in the general population.
- A systematic review and meta-analysis analyzed data from 248 studies to assess the geographic and ethnic distribution of these mutations, finding they are more common in populations living farther north of the Equator.
- Despite a significant association between AD and LoF FLG mutations in the Northern hemisphere, these mutations are less prevalent or absent in some ethnic groups, like Middle Easterners and most Africans, indicating a need for tailored AD management strategies.