Quantitative chemical profiling of cellulose acetate excipient via C NMR spectroscopy in controlled release formulations.

Cellulose acetate (CA) is the main component of controlled-release (CR) coating of formulations such as osmotic-controlled release oral delivery system (OROS) and CR microspheres. Despite multiple applications, there are limited or no reports dealing with the characterization and quantification of CA in the formulated systems. Thus, the present investigation deals with the development of the Quantitative Carbon-13 Nuclear Magnetic Resonance (qCNMR) spectroscopy method for the determination of CA amount in the CR microsphere formulations.

Computational Fluid Dynamics-Discrete Element Method Modeling of an Industrial-Scale Wurster Coater.

Large-scale fluid bed coating operations using Wurster coaters are common in the pharmaceutical industry. Experimental measurements of the coating thickness are usually analyzed for just few particles. To better predict the coating uniformity of the entire batch, computational techniques can be applied for process understanding of the key process parameters that influence the quality attributes.

Multivariate wavelet texture analysis for pharmaceutical solid product characterization.

The application of multivariate wavelet texture analysis (MWTA) is presented and discussed as it is applied to three different types of pharmaceutical materials: (a) tablet cores, (b) wet granules and (c) controlled release tablets. The application of MWTA is initially proposed as a quantitative replacement to the human visual judgment of the textural appearance of the different materials. In all cases, the metrics obtained with MWTA agree with visual assessment on the progression of textural features such as erosion and surface roughness.