Computational analysis of target genes in monkeypox virus infection and potential therapeutic precursors.

Background: Monkeypox is an orthopoxvirus that is responsible for zoonotic infections in humans. The virus has recently spread rapidly and the WHO has listed it as an international public health emergency of concern.

Research Design And Methods: Here, we used network analysis and gene enrichment protocols and analyzed datasets of MPXV infection that induced host cell gene expression list and subsequently mapped them against two herbal target gene lists which highlighted considerable coherence in pharmacological attributes with COVID-19.

Gender trend of monkeypox virus infection.

Introduction: An outbreak of monkeypox (mpox) in 2022 has been declared as a 'public health emergency of international concern' by the World Health Organization (WHO). There are many reports about the cases of male-to-male transmission of the recent mpox virus (MPXV). However, the mechanism and trend of male infection are unclear.

Recent advances on human mpox.

Mpox has been a concern of public health and travel caution. Using databases of WHO, CDC, google scholar, and PubMed, we searched recent literatures and reviewed the history, genomic mutation/evolution, host cell response pathways, regulation policy, vaccine and therapy development. Recent studies showed that current mpox has many genomic mutations related to regulation by APOBEC3.