Publications by authors named "Alan Bedrick"
Article Synopsis
- The study aimed to implement rapid whole genome sequencing (rWGS) in multiple hospitals to evaluate its clinical utility for infants suspected of having genetic diseases.
- Over 188 hospitalized infants were tested from November 2017 to April 2020, with 35% receiving a diagnostic result in an average of 6 days; providers significantly altered management plans for many based on test outcomes.
- Findings suggest that rWGS can be effectively integrated into clinical practice across diverse institutions, offering valuable insights into genetic conditions despite the presence of uncertain test results.
Cesarean birth has increased substantially in many parts of the world over recent decades and concerns have been raised about the propriety of this change in obstetric practice. Sometimes, a cesarean is necessary to preserve fetal and maternal health. But in balancing the risks of surgical intervention the implicit assumption has been that cesarean birth is an equivalent alternative to vaginal birth from the standpoint of the immediate and long-term health of the fetus and neonate.
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- - The study aims to understand how pediatric providers currently use pharmacogenetic testing (PGx) and to identify barriers they face when prescribing medications, emphasizing that children have different needs than adults in this context.
- - An online survey of 252 pediatric providers showed that while 24% had ordered PGx tests, over 90% felt more comfortable with expert assistance when interpreting the results, pointing to a need for better support and education.
- - The findings suggest that improving collaboration among healthcare professionals and increasing education about PGx testing are essential steps to overcome existing barriers and enhance patient care in pediatrics.
Article Synopsis
- Infants with neonatal abstinence syndrome (NAS) often require extended NICU stays and struggle with irritability, and babywearing through infant carriers is proposed to help comfort them and allow greater mobility for caregivers.
- A study involving 18 NICU nurses revealed six key themes related to the benefits of babywearing, including enhanced infant comfort and trust, as well as suggestions for improving the practice, focus on infection control, and education about carriers.
- While kangaroo care is common, babywearing is highlighted as a practical alternative for NICU staff to support the well-being of NAS infants while managing nursing responsibilities, indicating a need for further research on the long-term effects of this practice.
Accumulation of bile acids (BAs) may mediate development of necrotizing enterocolitis (NEC). Serial fecal samples were collected from premature infants with birth weight (BW) ≤ 1800 g, estimated gestational age (EGA) ≤ 32 weeks, and <30 days old prior to initiation of enteral feeding. Nine infants that developed Bell's Stage ≥ II NEC were matched with control infants based on BW, EGA, day of life (DOL) enteral feeding was initiated and DOL of the first sample.
View Article and Find Full Text PDFHigh rates of mathematics learning disabilities among individuals born preterm (<37weeksGA) have spurred calls for a greater understanding of the nature of these weaknesses and their neural underpinnings. Groups of healthy, high functioning young adults born preterm and full term (n=20) completed a symbolic and non-symbolic magnitude comparison task while undergoing functional MRI scanning. Collectively, participants showed activation in superior and inferior frontal and parietal regions previously linked to numeric processing when comparing non-symbolic magnitude arrays separated by small numeric distances.
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