Diterpenoids with Antibacterial Activities from the Fungus .

A new fusicoccane diterpenoid, harziaderma A (), two novel harziane diterpenoids, harzianones G and H ( and ), one revised harziane diterpenoid (), and two known diterpenoids ( and ) were isolated from the fungus and established via NMR, HRESIMS, Mo(OAc)-induced circular dichroism (ICD) and electronic circular dichroism (ECD) calculations. It is worth noting that compound represents the first instance of a fusicoccane-type diterpenoid derived from . The structure of furanharzianone B was revised to via careful spectroscopic analyses.

Proliferacorins A-M: Thirteen undescribed acorane sesquiterpenoids isolated from the fungus Fusarium proliferatum.

In this study, 13 previously undescribed acorane sesquiterpenoids, namely, proliferacorins A-M, were isolated from the solid fermentation of Fusarium proliferatum. Their structures and absolute configurations were confirmed via spectroscopic analyses, quantum-chemical NMR calculations with DP4+ probability analyses, ECD calculations and comparisons, and single-crystal X-ray diffraction techniques. Proliferacorins A-E (1-5) have a 7-oxa-tricyclo[6.

Enantiomeric α-pyrone derivatives with immunosuppressive activity from Talaromyces adpressus.

Five pairs of undescribed enantiomeric α-pyrone derivatives (±)-adprepyrones A-E (±1-±5), together with an unreported congener adprepyrone F (6), and 6-[(E)-3-Hydroxyprop-1-enyl]-4-methoxy-5-methyl-2-pyrone (7), recently reported as synthetic compound, were isolated from the fungus Talaromyces adpressus. Their structures with absolute configurations were elucidated by HRESIMS, 1D and 2D NMR, electronic circular dichroism calculations, and single-crystal X-ray diffraction analyses. (±)-Adprepyrone A (±1) possesses an unreported carbon skeleton formed by the fusion of an α-pyrone derivative with nicotinamide.