Publications by authors named "Alan Augusto Coelho"
Acta Cir Bras
February 2013
Article Synopsis
- A mouse model was developed using the 4T1 breast cancer cell line to study how low oxygen levels (hypoxia) affect cancer progression and spread.
- The method involved implanting the cells in mouse kidneys and inducing hypoxia using a clip, allowing researchers to analyze tumor changes and metastatic behavior.
- Results indicated that tumor hypoxia enhances the spread of cancer cells, with lung metastases observed only in hypoxic conditions after 14 days.
