Expression pattern analysis of the family genes in breast cancer patients and hypomethylation activation in the MCF-7 cells.

Melanoma antigen gene (MAGE) families are cancer-testis genes that normally show expression in the testes. However, their expressions have been linked with various types of human cancers, including BC. Therefore, the primary purposes of the present research were to assess the expression of , B, and C genes in Saudi female patients with BC and determine their regulation via the epigenetic mechanism.

Efficacy of various amendments for immobilization of potentially toxic elements in wastewater contaminated soils.

Farmers are using municipal wastewater either treated or untreated for irrigation because of limited fresh water resources. Wastewater extensively used for irrigation purposes is enriched with many nutrients. The reuse of wastewater is imposing a negative impact on human health and the ecosystem.

Olmutinib Reverses Thioacetamide-Induced Cell Cycle Gene Alterations in Mice Liver and Kidney Tissues, While Wheat Germ Treatment Exhibits Limited Efficacy at Gene Level.

: TAA is potent hepatic/renal toxicant. Conversely, WGO is a potent dietary supplement with impressive antioxidant properties. Olmutinib is an apoptotic chemotherapy drug that does not harm the liver or kidney.

Advanced hybrid silica nanoparticles with pH-responsive diblock copolymer brushes: optimized design for controlled doxorubicin loading and release in cancer therapy.

This study delves into the development, characterization, and application of modified mesoporous silica nanoparticles (MSNs) for targeted drug delivery in cancer therapy. MSNs were functionalized with poly(2-(diisopropylamino)ethyl methacrylate) (PDPA) and poly(glycidyl methacrylate) (PGMA), and further modified with cross-linkers DAE and Ornithine. Characterization using FT-IR, SEM, TEM, DLS, and XPS confirmed the successful surface modifications, revealing particle sizes primarily within the 63-94 nm range.

[1, 8]-Naphthyridine derivatives as dual inhibitor of alkaline phosphatase and carbonic anhydrase.

[1,8]-Naphthyridine derivatives have been reported to possess important biological activities and may serve as attractive pharmacophores in the drug discovery process. [1,8]-Naphthyridine derivatives (1a-1l) were evaluated for inhibitory potential for isozymes of carbonic anhydrase (CA) and alkaline phosphatase (ALP). CAs have been reported to carry out reversible hydration of CO into HCO, secretion of electrolytes, acid-base regulation, bone resorption, calcification, and biosynthetic reactions.

Synthesis, characterization and biological evaluation of pyrazole-based benzene sulfonamides as inhibitors of human carbonic anhydrase II, IX and XII.

The aberrant level of the carbonic anhydrase isozymes is linked with various disorders which include glaucoma, epilepsy, altitude sickness and obesity. In the present study, a series of the pyrazole-based benzene sulfonamides derivatives (4a-4l) were designed, synthesized and evaluated as the inhibitors of the three isoforms of human carbonic anhydrases (hCAII, hCAIX and hCAXII). A number of the derivatives were found more active inhibitors than acetazolamide used as a standard against the human hCAII, hCAIX and hCAXII.

Evaluation of the Effect of Wheat Germ Oil and Olmutinib on the Thioacetamide-Induced Liver and Kidney Toxicity in Mice.

Thioacetamide (TAA) intoxication produces a reproducible standard animal model of induced liver and kidney injuries where free radicals are produced by phase I oxidation reactions, which eventually leads to liver and kidney failure. Wheat germ oil (WGO) is a unique food supplement with concentrated nutrient efficiency and has remarkable antioxidant functions. Olmutinib, on the other hand, is a chemotherapy drug considered safe for kidneys and the liver.

Ameliorative Effect of Oxytocin on and Gene Expression, and Behavioral Patterns in Rats' Obesity-Induced Diabetes.

Amelioration of hyperinsulinemia and insulin resistance associated with obesity is a cardinal target for therapeutics. Therefore, we investigated the relation of ( expression and hepatic () enzyme to the ameliorative impact of oxytocin on obesity-induced diabetes, suggesting glycogenolysis markers in diabetic models. Four groups of forty male Wistar rats were formed ( = 10): a control group fed basal diet and peritoneal injections of saline; an oxytocin-injected group; a diet-induced obese group fed a high-fat/high-sugar diet and injected with saline; a diet-induced obese group injected with oxytocin.

Physio-biochemical responses and expressional profiling analysis of drought tolerant genes in new promising rice genotype.

Rice cultivation in Egypt is limited by the scarcity of water resources. The main strategy of rice breeders to overcome this problem is to develop new high-yielding varieties that are tolerant to drought stress. In this study, an drought-tolerant (IR60080-46A) variety was crossed with commercial Egyptian varieties using the back-cross method and marker-assisted selection (MAS) approach.

Splice-disrupt genomic variants in prostate cancer.

Background: Splice-disrupt genomic variants are one of the causes of cancer-causing errors in gene expression. Little is known about splice-disrupt genomic variants.

Methods And Results: Here, pattern of splice-disrupt variants was investigated using 21,842,764 genomic variants in different types of prostate cancer.

Identification of C-T novel polymorphism in 3rd exon of OsSPL14 gene governing seed sequence in rice.

Recently food shortage has become the major flagging scenario around the globe. To resolve this challenge, there is dire need to significantly increase crop productivity per unit area. In the present study, 24 genotypes of rice were grown in pots to assess their tillering number, number of primary and secondary branches per panicle, number of grains per panicle, number of grains per plant, and grain yield, respectively.

Chemical Composition of Essential Oil and Its Potential Antioxidant and Antimicrobial Activities.

The exploration of new bioactive compounds from natural resources as alternatives to synthetic chemicals has recently attracted the attention of scientists and researchers. To our knowledge, the essential oil (EO) of has not yet been explored. Thus, the present study was designed to explore the EO chemical profile of for the first time, as well as evaluate its antioxidant and antibacterial activities, particularly the extracts of this plant that have been reported to possess various biological activities.

Seed Priming Boost Adaptation in Pea Plants under Drought Stress.

In the present investigation, we study the effect of MH161336 (10 CFU/cm), silicon (25 mL L), and carrot extract (75 mL L) as seed primers, individually or in combination, on morphological, physio-biochemical and yield components of drought-stressed pea plants (Master B) during 2019/2020 and 2020/2021 seasons. Our results indicated that drought causes a remarkable reduction in plant height, leaf area, number of leaves per plant, and number of flowers per plant in stressed pea plants during two seasons. Likewise, number of pods, pod length, seeds weight of 10 dried plants, and dry weight of 100 seeds were decreased significantly in drought-stressed pea plants.

Impact of metal nanoparticles on the structure and function of metabolic enzymes.

The widespread use of nanoparticles raises many serious concerns about the safety and environmental impact of nanoparticles. Therefore, risk assessments of specific nanoparticles in occupational and environmental exposure are essential before their large-scale production and applications, especially in medicine and for usage in household items. In this study, the effects of five different metal nanoparticles on the structure, stability, and function of four metabolic enzymes were evaluated using various biophysical techniques.

Thiourea Derivatives, Simple in Structure but Efficient Enzyme Inhibitors and Mercury Sensors.

In this study six unsymmetrical thiourea derivatives, 1-isobutyl-3-cyclohexylthiourea (), 1-butyl-3-cyclohexylthiourea (), 1-(3-chlorophenyl)-3-cyclohexylthiourea (), 1-(1,1-dibutyl)-3-phenylthiourea (), 1-(2-chlorophenyl)-3-phenylthiourea () and 1-(4-chlorophenyl)-3-phenylthiourea () were obtained in the laboratory under aerobic conditions. Compounds and are crystalline and their structure was determined for their single crystal. Compounds is monoclinic system with space group P2/n while compound is trigonal, space group .

Potency of plant extracts against Penicillium species isolated from different seeds and fruits in Saudi Arabia.

Antifungal activity of extracts of cinnamon (Cinnamomum zeylanicum), Cloves (Syzygium aromaticum), ginger (Zingiber officinale) and turmeric (Curcuma longa) were evaluated against 17 . Seed disease and rotten fruit caused by these species cause considerable loss of quality for different agricultural products. Isolates of spp.

Molecular mechanisms underlying antitumor activity of camel whey protein against multiple myeloma cells.

Treating drug-resistant cancer cells is a clinical challenge and it is also vital to screen for new cancer drugs. Multiple myeloma (MM) is a plasma cell clonal cancer that, despite many experimental therapeutics, remains incurable. In this study, two MM cell line lines U266 and RPMI 8226 were used to determine the impact of camel whey protein (CWP).

Corrigendum to "Structural and functional characterization of Tomato gene" [Saudi J. Biol. Sci. 27(1) (2020) 352-357].

[This corrects the article DOI: 10.1016/j.sjbs.

Induction of liver fibrosis by CCl4 mediates pathological alterations in the spleen and lymph nodes: The potential therapeutic role of propolis.

In an animal models, carbon tetrachloride (CCl) is a carcinogenic agent that causes liver fibrosis. The current study aims to investigate whether induction in liver-fibrosis by CCl in the mouse model could promote the initiation of fibrosis in lymph node and spleen due to sustained increase of inflammatory signals and also aimed to clarify the protective therapeutic effects of propolis. The male mice (BALB/c) were categorized into three experimental sets and each group involved 15 mice.