Do Gadolinium-Based Contrast Agents Affect F-FDG PET/CT Uptake in the Dentate Nucleus and the Globus Pallidus? A Pilot Study.

Gadolinium is toxic and to avoid its deposition in tissues, it must be chemically bonded with nonmetal ions to facilitate its excretion by the kidneys. High signal intensity in the dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted MR images has been both morphologically and pathologically linked to gadolinium-based contrast agent (GBCA) retention in the brain. The purpose of this study was to determine whether repeated administrations of GBCA would affect the uptake of F-FDG in the DN and GP on PET/CT.