Publications by authors named "Alain-Marie Bron"
Article Synopsis
- * The study aims to investigate the transport dysfunction of long-chain polyunsaturated fatty acids (LC-PUFA) in the fetoplacental unit and its link to ROP by evaluating the relationship between placental fatty acid receptor expression and ROP occurrence.
- * If the study finds a correlation, it could identify new mechanisms behind ROP, thereby aiding in public health strategies to prevent this condition in vulnerable infants.
Article Synopsis
- A nationwide cohort study in France examined the use of intravitreal injections (IVTs) of anti-VEGF agents and corticosteroids in pregnant women, focusing on obstetric and neonatal complications.
- From 2009 to 2018, only 228 IVTs were given to 139 pregnant women out of over 5.6 million total IVTs performed in the country.
- The study found a high incidence of obstetric complications among those receiving anti-VEGF (16.1% had spontaneous abortion or termination) compared to corticosteroids (3.1%), but no statistically significant link was established between the injections and these complications, highlighting the need for caution in their use during pregnancy.
Article Synopsis
- The study aimed to evaluate the occurrence and effects of cystoid macular edema (CME) following surgery for retinal detachment and to identify risk factors associated with it.
- Conducted over 5 years, the study analyzed 493 adult patients who underwent pars plana vitrectomy (PPV) for primary rhegmatogenous retinal detachment, finding a 28% rate of CME at 12 months post-surgery.
- Risk factors for developing CME included poorer initial visual acuity, severe proliferative vitreoretinopathy, the use of endolaser retinopexy, and undergoing cataract surgery within 6 months of the primary repair.
Article Synopsis
- This study aimed to investigate the effects of docosahexaenoic acid (DHA) as an antifibrotic treatment following glaucoma filtration surgery (GFS) in rats.
- The experiment included 36 rats divided into three groups: a control group, a DHA group, and a mitomycin C (MMC) group, with measurements of intraocular pressure (IOP) and observed changes in fibroblast activity.
- Results showed that both the DHA and MMC groups maintained lower IOP and larger bleb areas compared to the control group, indicating that DHA has potential similar effects to MMC, warranting further research.
Article Synopsis
- The study focused on mobile screening for diabetic retinopathy (DR) using retinal photographs in rural and periurban regions, comparing results before and after the COVID-19 lockdown.
- Since 2004, over 10,000 patients were screened, revealing that about 13.9% had DR, with average profiles showing higher blood sugar levels and longer diabetes duration in affected individuals.
- No significant differences were found in screening results between rural and periurban areas or pre- and post-lockdown, highlighting the effectiveness of mobile telemedicine for early DR detection, especially in underserved rural populations.
Article Synopsis
- - A 25-year-old healthy woman developed bilateral acute macular neuroretinopathy after receiving the first dose of the Oxford-AstraZeneca COVID-19 vaccine, presenting with black spots in her vision.
- - Her symptoms started 24 hours post-vaccination, following mild fever and flu-like symptoms, but her visual acuity remained normal during examination.
- - The case highlights the need for awareness among physicians about potential vision-related side effects following vaccination and suggests that young women on oral contraceptives may require closer monitoring.
Purpose: The aim of this study was to investigate the prevalence of subretinal drusenoid deposits (SDD) and to identify associated factors in an elderly population.
Methods: The participants of the population-based Montrachet study underwent an exhaustive ophthalmologic examination, including color fundus photography and macular spectral domain-optical coherence tomography (SD-OCT), coupled with infrared reflectance imaging. The presence of SDD and other age-related macular degeneration lesions, according to the European Eye Epidemiology SD-OCT classification of macular diseases, and subfoveal choroidal thickness were recorded.
Article Synopsis
- The study aimed to measure subfoveal choroidal thickness (SFCT) in individuals over 75 years old and explore its relationship with cardiovascular history and the risk of fatal cardiovascular disease (CVD).
- A total of 764 participants were analyzed, with findings indicating that increased age and longer axial length correlated with thinner SFCT, but SFCT showed no significant connection to cardiovascular history or risk factors.
- The research concludes that while older age and longer axial length lead to a decrease in SFCT, SFCT cannot be considered a reliable biomarker for assessing cardiovascular risk in this demographic.
Iodinated contrast agent (ICA)-induced acute kidney injury (AKI) following acute coronary syndrome (ACS) is a frequent complication, which may lead to chronic kidney disease and increased mortality. Optical coherence tomography angiography (OCT-A) of the retina is new tool delivering a rapid and noninvasive assessment of systemic microvascularization, which is potentially involved in the occurrence of ICA-induced AKI. Between October 2016 and March 2017, 452 ACS patients were admitted to our cardiac intensive care unit.
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- This study assessed the safety and effectiveness of repeated dexamethasone implants over three years in patients with macular edema due to either branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO).
- A total of 66 patients participated, with some receiving only dexamethasone implants while others first received implants and then switched to anti-VEGF treatments.
- Key findings included a significant improvement in best-corrected visual acuity (BCVA) and reductions in central retinal thickness (CRT) after treatment, although adverse events like cataract extraction and elevated intraocular pressure were common.
Article Synopsis
- This study investigates factors predicting visual acuity recovery 1 year after cataract and idiopathic epiretinal membrane surgery, emphasizing the development of a new predictive score.
- It followed 142 patients for 12 months and found that age, duration of symptoms, initial best-corrected visual acuity, and disruptions in retinal imaging were significant indicators of recovery.
- The resulting 10-point predictive score demonstrated high sensitivity (82%) and specificity (66%), allowing for better estimation of visual outcomes based on individual patient characteristics.
Article Synopsis
- The study aimed to evaluate how well patients adhered to taking brimonidine eye drops, either twice daily (bid) or three times daily (tid), over a period of 4 weeks.
- Out of 75 enrolled patients, 67 completed the study, revealing significant issues with adherence: many patients missed doses, and the bid group showed better adherence compared to the tid group.
- Results indicated that a substantial portion of patients had poor medication coverage, especially those with normal-tension glaucoma, highlighting the need for improved adherence strategies and drug delivery methods in treating glaucoma.