Publications by authors named "Alain Vazi"
Article Synopsis
- Lupus nephritis (LN) is a serious condition linked to Systemic Lupus Erythematosus (SLE), and currently, kidney biopsy results are essential for treatment decisions.
- A study analyzed urinary samples from 93 patients to see if urinary peptidome analysis could reliably distinguish between active and non-active LN without the need for biopsy.
- The findings indicated that urinary peptides couldn't effectively differentiate active from non-active LN or predict therapy responses, although certain classifiers (CKD273 and LN172) were validated without replacing the need for kidney biopsies.
Background: The purpose of this trial was to evaluate the efficacy of a low-animal-protein diet (LAPD) or a high-fiber diet (HFD) for the prevention of calcium nephrolithiasis recurrence.
Methods: We conducted a 4-year randomized trial comparing the effect of 2 diets in 175 idiopathic calcium stone formers. Fifty-five were assigned to a LAPD (<13% of total energy derived from protein), 60 were assigned to a HFD (>25 g/day fiber) and 60 were placed on a normal diet (control group).
Objective: We optimized of the preparation of urinary samples to obtain a comprehensive map of urinary proteins of healthy subjects and then compared this map with the ones obtained with patient samples to show that the pattern was specific of their kidney disease.
Design And Methods: The urinary protein excretion patterns of 49 healthy men and 4 patients with renal disease were obtained by 2D electrophoresis. Silver nitrate stained protein spots were identified by mass spectrometry.