Publications by Alain Sarabia Pacis

Publications by authors named "Alain Sarabia Pacis"

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Direct AKT activation in tumor-infiltrating lymphocytes markedly increases interferon-γ (IFN-γ) for the regression of tumors resistant to PD-1 checkpoint blockade.

François Santinon Bennani Fatima Ezzahra Meriem Bachais Alain Sarabia Pacis Christopher E Rudd

Sci Rep

November 2022

Article Synopsis

- PD-1 immune checkpoint blockade has changed cancer treatment by impacting how T-cells respond to tumors, but PD-1 inhibits key activators like AKT, making some tumors resistant to this therapy.
- Researchers investigated the effect of a small molecule activating AKT (SC79) on tumor growth, finding it not only reduced the presence of suppressing T-cells (Tregs) but also boosted effector T-cell activity in resistant tumor models.
- The activation of AKT led to increased production of interferon-γ (IFN-γ) in CD4+ and CD8+ TILs, transforming Tregs into helper T-cells and enhancing overall anti-tumor immunity, revealing potential new

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Single-Cell RNA-Seq Analysis of Cells from Degenerating and Non-Degenerating Intervertebral Discs from the Same Individual Reveals New Biomarkers for Intervertebral Disc Degeneration.

Hosni Cherif Matthew Mannarino Alain Sarabia Pacis Jiannis Ragoussis Oded Rabau

Int J Mol Sci

April 2022

In this study, we used single-cell transcriptomic analysis to identify new specific biomarkers for nucleus pulposus (NP) and inner annulus fibrosis (iAF) cells, and to define cell populations within non-degenerating (nD) and degenerating (D) human intervertebral discs (IVD) of the same individual. Cluster analysis based on differential gene expression delineated 14 cell clusters. Gene expression profiles at single-cell resolution revealed the potential functional differences linked to degeneration, and among NP and iAF subpopulations.

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