Publications by authors named "Alain Raisonnier"
Article Synopsis
- Hyperhomocyteinemia (HHcy) is linked to increased risk of coronary artery disease (CAD), and specific genetic mutations in MTHFR, MTR, and MTRR impact homocysteine levels.
- CAD patients displayed significantly higher total homocysteine levels compared to controls, with smokers also showing elevated levels and a greater risk for CAD.
- The MTHFR 1298C allele was more common in CAD patients and associated with risk for HHcy, while no significant differences were found for other mutations in MTR and MTRR.
Influence of methionine synthase (A2756G) and methionine synthase reductase (A66G) polymorphisms on plasma homocysteine levels and relation to risk of coronary artery disease.
Acta Cardiol
February 2006
Background: Elevated plasma total homocysteine (tHcy) is increasingly being recognized as a risk factor for coronary artery disease (CAD) and other defects. Recent genetic studies have characterized molecular determinants contributing to altered homocysteine metabolism. Our objectives were therefore to confirm the relationship of tHcy with CAD and to examine the importance of genetic influence on tHcy in the coronary angiograms and conventional cardiovascular risk factors recorded in 230 subjects.
View Article and Find Full Text PDFObjectives: In severe type IV hypertriglyceridemia (triglyceride levels >10 g/l), it is yet unknown whether lipoprotein lipase (LPL) differs according to the presence or not of diabetes.
Methods: We compared LPL activity and the presence of four common variants in the LPL gene (Asp 9 Asn (exon 2), Gly 188 Glu (exon 5), Asn 291 Ser (exon 6) and Ser 447 Ter (exon 9)) in a group of 34 patients of whom 17 presented diabetes mellitus.
Results: Maximum triglyceride, cholesterol levels and distribution of apolipoprotein E phenotypes did not differ between the two subgroups.