Publications by authors named "Alain Marques-Verdier"
Article Synopsis
- Cirrhosis alters hemostatic balance, reducing both procoagulant and anticoagulant factors, making traditional tests ineffective for assessing thrombotic risk.
- This study analyzed coagulation in 30 cirrhotic patients using thrombinography, revealing significantly higher thrombin potential ratios compared to healthy controls, indicating a resistance to activated protein C pathways.
- Findings suggest that rather than being anticoagulated, cirrhotic patients may experience increased hypercoagulability, especially with advanced disease severity, challenging existing beliefs about their coagulation status.*
The few cases of antiphospholipid syndrome that have been reported in neonates are believed to have resulted from a transplacental transfer of antiphospholipid antibodies. Here we report on a boy with a neonatal stroke revealing a de novo primary antiphospholipid, the mother being free of antiphospholipid antibodies. Other thrombosis risk factors included primiparity, gestational diabetes, macrosomia, polyglobulia, and lipoprotein(a) >30 mg/dL.
View Article and Find Full Text PDFAcquired inhibitors to factor V are considered rare events and the cause is often unknown. Diagnostic haemostasis assays to correctly assess this phenomenon are not always perfect and reproducible. Various treatments have been attempted but a standardised management of patients is still lacking.
View Article and Find Full Text PDFIntroduction: Bronchoalveolar fibrin deposition is a characteristic of various lung disorders including acute lung injury, acute respiratory distress syndrome and sepsis. It is secondary to the activation of coagulation and inhibition of fibrinolysis in the alveolar space, and can be stimulated by lipopolysaccharide (LPS) inhalation. The aim of this study was to determine the relation between compartmental stress in the lung and systemic response after LPS inhalation by measuring haemostatic parameters.
View Article and Find Full Text PDFA 17-year-old girl presented with Neisseria meningitidis sepsis, with evidence of disseminated intravascular coagulation. Substitution therapy with both antithrombin and protein C concentrates was initiated, leading to clinical and biological improvement. Sequential dosages were performed for biological markers including thrombin-activatable fibrinolysis inhibitor (TAFI).
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