Publications by authors named "Alain Archimbaud"
Article Synopsis
- About 50% of melanoma cases have the BRAF V600 mutation, which activates the MAP kinase pathway and responds well to BRAF inhibitors, but the effectiveness usually lasts only about 6 months.
- A study involving nine patients who previously benefited from BRAF inhibitors found that some patients had positive responses when treated again after disease progression.
- Findings suggest that alternating treatments, such as BRAF inhibitors following intercurrent treatments like ipilimumab, may be beneficial and merit further investigation in clinical trials.
Ultrasound-guided core needle biopsy of superficial lymph nodes: an alternative to fine-needle aspiration cytology for the diagnosis of lymph node metastasis in cutaneous melanoma.
Melanoma Res
December 2015
To investigate the diagnostic value of ultrasound-guided core needle biopsy (US-CNB) in suspected cases of lymph node metastasis from cutaneous melanoma. All patients with cutaneous melanoma followed in Saint-Louis Hospital between 2006 and 2010 who underwent US-CNB for suspicion of melanoma lymph node metastasis were reviewed retrospectively. Histopathological results of US-CNB samples were classified as melanoma, other malignancy, suspicious, inadequate, or benign.
View Article and Find Full Text PDFObjectives: To evaluate the prognostic value of melanocytic differentiation antigens and angiogenesis biomarkers in sentinel lymph nodes (SLNs) with melanoma micrometastases.
Design: Prognostic study of an inception cohort.
Setting: Academic research.
The endothelin signaling pathway plays a crucial role in melanocyte differentiation and migration. In this study, we investigated whether germline mutations of endothelin receptor B (EDNRB), a gene involved in Hirschsprung disease (HSCR), could also predispose for malignant melanoma (MM). The coding region of EDNRB was sequenced in 137 MM patients and in 130 ethnically matched Caucasian control subjects.
View Article and Find Full Text PDFThe occuloalbinism 2 (OCA2) gene, localized at 15q11, encodes a melanosomal transmembrane protein that is involved in the most common form of human occulo-cutaneous albinism, a human genetic disorder characterized by fair pigmentation and susceptibility to skin cancer. We wondered whether allele variations at this locus could influence susceptibility to malignant melanoma (MM). In all, 10 intragenic single-nucleotide polymorphisms (SNPs) were genotyped in 113 patients with melanomas and in 105 Caucasian control subjects with no personal or family history of skin cancer.
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