[The effect of ethacrynic acid on the functions of the gastrointestinal tract].

During in vitro and in situ experiments ethacrynic acid was shown to reduce the gastric secretion in rats, motility of the small intestine in rats and mice, contractions of the ileum of guinea pigs in response to histamine and acetylcholine. The intestinal water and electrolyte absorption in rats decreased too. All these effects of ethacrynic acid are extrarenal.

[Effect of diuretics on the absorption of glucose in rat small intestine].

During acute experiments on rats with perfusion of the rat jejunum portion in situ it was shown that ethacrynic acid (10(-4) M) and novurit (10(-4) M) suppress glucose and water absorption. Furosemide (2.10(-3) M) and dichlothiazide (2.