Publications by authors named "Aladine Elsamadicy"

Introduction: Safety net hospitals (SNH) serve a large proportion of patients with Medicaid or without insurance. However, few prior studies have addressed the impact of SNH status on outcomes following anterior cervical discectomy and fusion (ACDF) or posterior cervical decompression and fusion (PCDF) for cervical spondylotic myelopathy (CSM). The aim of this study was to assess the association between SNH status outcomes following ACDF or PCDF for CSM.

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Introduction: Many patients with cervical spondylotic myelopathy (CSM) undergo anterior cervical discectomy and fusion (ACDF). Many of these patients are readmitted, but there is no clear understanding of drivers of readmission. The aim of this study was to assess the patient- and hospital-level factors that contribute to 7-, 30-, and 90-day readmissions after treatment of CSM.

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While women tend to experience more severe psychiatric and neurobehavioral symptoms following traumatic brain injury (TBI), the connection between sex and post-TBI depression remains poorly understood. To explore the potential association between sex and post-TBI depression, we conducted a systematic review and meta-analysis, including studies with participants who had no prior diagnosis of depression. Thirteen studies met the criteria for inclusion, collectively investigating a cohort of 449,471 individuals with TBI.

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Objective: Nutritional status has been shown to impact patient outcomes across several neurosurgical procedures. However, few prior studies have assessed associations between preoperative nutritional status and outcomes in elderly patients undergoing subdural hematoma evacuations. The aim of this study was to identify associations between preoperative nutritional status and short-term outcomes in patients aged 65 years and older undergoing subdural hematoma evacuation.

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Introduction: Bladder dysfunction and associated complications of the urinary system negatively impact the quality of life in children living with spinal cord injury (SCI). Pediatric lower urinary tract deficits include bladder over-activity, inefficient emptying, decreased compliance, and incontinence. Recent evidence in adults with SCI indicates significant improvements in bladder capacity and detrusor pressure following participation in an activity-based recovery locomotor training (ABR-LT) rehabilitative program.

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We sought to identify long-term associations of medical complications and healthcare utilization related to polypharmacy following spinal surgery for degenerative lumbar pathology. The IBM MarketScan dataset was used to select patients who underwent spinal surgery for degenerative lumbar pathology with 2-year follow-up. Regression analysis compared two matched cohorts: those with and without polypharmacy.

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Study Design: A retrospective cohort study.

Purpose: To examine the effect of cannabis use history on postoperative opioid utilization in patients undergoing one- to three-level lumbar fusion for degenerative spine disease.

Overview Of Literature: Strategies to minimize dosing and chronic opioid use are needed for spine surgery given their widespread prescription for postsurgical pain management.

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Article Synopsis
  • This study focuses on the ability of the Risk Analysis Index (RAI) and modified 5-item Frailty Index (mFI-5) to predict outcomes like extended length of stay, complications, and readmissions in patients undergoing spinal surgery for deformities.
  • Researchers analyzed data from over 3,800 patients and found that both RAI and mFI-5 were significant predictors of longer hospital stays, with RAI being better for predicting readmissions and mFI-5 better for predicting complications.
  • The results suggest that these frailty assessments can improve preoperative planning, but more research is needed to integrate these tools effectively in clinical practices.
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  • A study examined how opioid consumption affects hospital stay lengths after posterior spinal fusion in adolescents with idiopathic scoliosis, using data from the Premier Healthcare Database from 2016-2017.
  • Patients were categorized based on their morphine milligram equivalent (MME) intake into Low, Medium, and High groups, with a focus on demographics, post-operative complications, and costs.
  • Results showed that a higher opioid intake was linked to longer hospital stays, with 19.7% of High cohort patients experiencing extended stays compared to 6.5% of Low cohort patients, while the Low cohort faced higher admission costs.
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Background: Risk Analysis Index (RAI) has been increasingly used to assess surgical frailty in various procedures, but its effectiveness in predicting mortality or in-patient hospital outcomes for spine surgery in metastatic disease remains unclear. The aim of this study was to compare the predictive values of the revised RAI (RAI-rev), the modified frailty index-5 (mFI-5), and advanced age for extended length of stay, 30-day readmission, complications, and mortality among patients undergoing spine surgery for metastatic spinal tumors.

Methods: A retrospective cohort study was performed using the 2012-2022 ACS NSQIP database to identify adult patients who underwent spinal surgery for metastatic spinal pathologies.

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Article Synopsis
  • The study is a retrospective cohort analysis aimed at understanding the impact of surgical infections in spine surgery, which can occur in up to 16% of cases.
  • It involved 410,930 adult patients from the ACS NSQIP database, categorizing them into those with surgical infections and those without, while analyzing various health outcomes.
  • Results showed that patients with surgical infections experienced significantly higher complications, including adverse events, longer hospital stays, non-routine discharges, unplanned readmissions, and increased mortality rates.
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Objective: To determine the impact of epidural spinal injections (ESIs) on postoperative surgical complications.

Methods: This retrospective all-payer database analysis identified 202,181 adult patients undergoing one- to three-level transforaminal lumbar interbody fusion (TLIF) from 2010 to 2020. A 1:1 exact matching on comorbidities and demographics was performed, creating 2 cohorts: 1) patients who received an ESI within 90 days of surgery and 2) patients who did not receive an ESI.

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Article Synopsis
  • Intraventricular hemorrhage (IVH) primarily affects newborns with low gestational age and weight, necessitating critical care and potentially leading to long-term developmental issues; assessing regional care differences in the U.S. can help address socioeconomic disparities in treatment and outcomes.
  • A study analyzing data from 2016-2019 identified 1,630 newborns with IVH and examined demographics and hospital outcomes, revealing significant variations in race and ethnicity among regions, particularly higher percentages of Black patients in the Midwest and South, and Hispanic patients in the South and West.
  • Results indicated no significant differences in length of stay across regions; however, the West had the highest admission costs, while the South showed lower odds of exorbitant
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The relationship between psychiatric disorders, including depression, and invasive interventions has been a topic of debate in recent literature. While these conditions can impact the quality of life and subjective perceptions of surgical outcomes, the literature lacks consensus regarding the association between depression and objective perioperative medical and surgical complications, especially in the neurosurgical domain. MEDLINE (PubMed), EMBASE, PsycINFO, and the Cochrane Library were queried in a comprehensive manner from inception until 10 November 2023, with no language restrictions, for citations investigating the association between depression and length of hospitalization, medical and surgical complications, and objective postoperative outcomes including readmission, reoperation, and non-routine discharge in patients undergoing spine surgery.

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Article Synopsis
  • The study examines how insurance status (Medicaid vs. Private Insurance) impacts healthcare outcomes for newborns with intraventricular hemorrhage, focusing on adverse events, length of stay, and costs.
  • A retrospective analysis of data from 2016-2019 found demographic differences between Medicaid and Private Insurance patients, with Medicaid patients generally having longer hospital stays and higher total costs.
  • Though significant disparities in demographics, length of stay, and costs exist, insurance status itself did not independently predict increased healthcare utilization, suggesting the need for more research on this issue.
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  • The study aimed to determine if race and ethnicity affect postoperative outcomes for pediatric patients undergoing cranial vault repair for craniosynostosis, including complication rates and hospital stay duration.
  • The analysis included a cohort of 7,764 patients categorized into four racial groups, assessing demographics, surgical outcomes, and hospital resource usage through multivariate logistic regression.
  • Results indicated that non-Hispanic White (NHW) patients had fewer adverse events and shorter hospital stays compared to non-Hispanic Black (NHB) patients, while race was identified as an independent predictor of extended length of stay, particularly for NHB and other racial categories.
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Antifibrinolytics have gained increasing attention in minimizing blood loss and mitigating the risks associated with massive transfusions, including infection and coagulopathy in pediatric patients undergoing spine surgery. Nevertheless, the selection of optimal agent is still a matter of debate. We aim to review the utility of these agents and compare the efficacy of antifibrinolytics in pediatric and adolescent spine surgeries.

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Background: Isolated unilateral alar ligament injury (IUALI) is a rare and likely underreported occurrence after upper cervical trauma, with only 16 cases documented in the literature to date. Patients generally present with neck pain, and definitive diagnosis is typically made by magnetic resonance imaging (MRI). Unfortunately, likely due in part to its rarity, there are no formal guidelines for the treatment of an IUALI.

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  • - The study investigates how malnutrition affects surgical outcomes in patients with spinal metastases, focusing on complications and healthcare resource use after surgery.
  • - Researchers analyzed data from the 2011-2019 American College of Surgeons National Surgical Quality Improvement Program, comparing two groups: Nourished (healthy serum albumin levels) and Malnourished (lower serum albumin levels).
  • - Results showed that 26% of patients were malnourished, which correlated with higher rates of adverse events and complications compared to nourished patients, indicating that malnutrition significantly affects recovery outcomes.
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Introduction: Intraventricular hemorrhage (IVH) can ensue permanent neurologic dysfunction, morbidity, and mortality. While previous reports have identified disparities based on patient gender or weight, no prior study has assessed how race may influence in neonatal or infantile IVH patients. The aim of this study was to investigate the impact of race on adverse event (AE) rates, length of stay (LOS), and total cost of admission among newborns with IVH.

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Objective: The influence of socioeconomic factors on racial disparities among patients with sporadic meningiomas is well established, yet other potential causative factors warrant further exploration. The authors of this study aimed to determine whether there is significant variation in the genomic profile of meningiomas among patients of different races and ethnicities and its correlation with clinical outcomes.

Methods: The demographic, genomic, and clinical data of patients aged 18 years and older who had undergone surgery for sporadic meningioma between September 2008 and November 2021 were analyzed.

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Introduction: Interspinous devices (ISDs) and interlaminar devices (ILDs) are marketed as alternatives to conventional surgery for degenerative lumbar conditions; comparisons with decompression alone are limited. The present study reviews the extant literature comparing the cost and effectiveness of ISDs/ILDs with decompression alone.

Methods: Articles comparing decompression alone with ISD/ILD were identified; outcomes of interest included general and disease-specific patient-reported outcomes, perioperative complications, and total treatment costs.

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Introduction: Several studies have demonstrated the benefits of enhanced recovery after surgery (ERAS) protocols for patients with adolescent idiopathic scoliosis (AIS) undergoing posterior spinal instrumented fusion (PSIF). However, there are relatively few studies investigating the effect of regular multidisciplinary team meetings on level selection, surgical performance parameters, and patient outcomes after PSIF for AIS. The aim of this study was to assess changes in intra- and postoperative outcomes following multidisciplinary team meeting implementation for patients undergoing PSIF for AIS.

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Purpose: Primary osseous neoplasms of the spine, including Ewing's sarcoma, osteosarcoma, chondrosarcoma, and chordoma, are rare tumors with significant morbidity and mortality. The present study aims to identify the prevalence and impact of racial disparities on management and outcomes of patients with these malignancies.

Methods: The 2000 to 2020 Surveillance, Epidemiology, and End Results (SEER) Registry, a cancer registry, was retrospectively reviewed to identify patients with Ewing's sarcoma, osteosarcoma, chondrosarcoma, or chordoma of the vertebral column or sacrum/pelvis.

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: Frailty has been shown to negatively influence patient outcomes across many disease processes, including in the cervical spondylotic myelopathy (CSM) population. The aim of this study was to assess the impact that frailty has on patients with CSM who undergo anterior cervical discectomy and fusion (ACDF) or posterior cervical decompression and fusion (PCDF). : A retrospective cohort study was performed using the 2016-2019 national inpatient sample.

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