Publications by authors named "Aladawi M"
Objective: The aim of this study is to evaluate the 100 most highly cited articles assessing posterior communicating artery aneurysms.
Methods: In May 2024, a comprehensive search was conducted in the Scopus database using the keyword "posterior communicating artery aneurysm" The top-100 most impactful articles were ranked by citation count and analyzed for relevant factors. Citations per year were calculated to minimize the risk of bias.
Article Synopsis
- Preventing rebleeding in aneurysmal subarachnoid hemorrhage (SAH) is important, and lowering systolic blood pressure (SBP) may help, although evidence is not clear-cut.
- A systematic review analyzed ten studies, finding that higher SBP is linked to a greater chance of rebleeding, while maintaining SBP ≤160 mmHg reduced this risk significantly.
- The results should be approached cautiously due to variability in study designs, highlighting the need for more standardized future research to better understand blood pressure's role in rebleeding risk.
Background Informed consent is an essential component of medical practice, particularly in surgical procedures, as it guarantees that patients are thoroughly informed of the risks, benefits, and alternatives prior to receiving treatment. Nevertheless, research has demonstrated that patients frequently fail to recall critical information that was conveyed during the informed consent process, which emphasizes the potential for communication and comprehension deficiencies. Objective The objective of this study was to evaluate the quality of informed consent and the decision-making preferences of patients who are undergoing surgical procedures.
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- Reversible Cerebral Vasoconstriction Syndrome (RCVS) is characterized by the constriction and dilation of cerebral blood vessels, but its underlying causes are not fully understood.
- Two cases of RCVS linked to the drug teprotumumab were reported, involving two women with Graves' eye disease who experienced symptoms like leg weakness and severe headaches after starting the medication.
- Both patients showed improvement after treatment with verapamil, leading to concerns about the potential role of teprotumumab in triggering RCVS, warranting further research into this connection.
Article Synopsis
- * A review highlights the connection between PD, new-onset seizures, and pyridoxine deficiency, using case reports that show seizures often occur with high-dose dopaminergic therapy and underlying vitamin deficiencies, despite other tests returning normal results.
- * The study emphasizes the importance of monitoring pyridoxine levels in PD patients, particularly those experiencing dietary issues or undergoing significant medication changes, to improve patient care and quality of life by potentially reducing seizure risks.
Background: Recent studies indicate endovascular thrombectomy (EVT) as a safe, effective treatment for acute ischemic stroke (AIS) with large ischemic regions. Our study updates an ongoing living systematic review and meta-analysis of randomized controlled trials (RCTs) comparing outcomes of EVT to medical management only.
Methods: We searched MEDLINE, EMBASE, and the Cochrane Library for RCTs comparing EVT to medical management in AIS patients with large ischemic areas.
Dual antiplatelet therapy versus intravenous tissue plasminogen activator with acute minor ischemic stroke: A systematic review and meta-analysis of safety and efficacy.
J Stroke Cerebrovasc Dis
July 2024
Article Synopsis
- This study aimed to compare the safety and effectiveness of Dual Antiplatelet Therapy (DAPT) versus Intravenous Tissue Plasminogen Activator (IV t-PA) for treating minor Acute Ischemic Stroke (AIS).
- A meta-analysis of five studies involving nearly 6,200 patients found no significant differences in treatment efficacy based on modified Rankin scale scores or mortality rates between the two therapies.
- DAPT showed a notably lower risk of bleeding and symptomatic intracranial hemorrhage compared to IV t-PA, suggesting it may be a safer option.
Introduction: Cases of Guillain-Barré Syndrome (GBS) have been believed to be associated with the novel COVID-19 infection, and also with the following vaccines developed against the infection. Our work aims to investigate the incidence of GBS after COVID-19 vaccination, and describe its clinical characteristics and potential confounders.
Methods: An electronic search was conducted through four databases: PubMed, Scopus, medRxiv, and Google Scholar for all case reports and case series describing after COVID-19 vaccine administration.
Article Synopsis
- Endovascular thrombectomy (EVT) is the main treatment for acute ischemic stroke due to large-vessel blockage, but there’s ongoing debate about the best blood pressure control after the procedure.
- This study aimed to compare the effects of different systolic blood pressure targets on patient outcomes, mortality, and complications after EVT in ischemic stroke patients.
- A systematic review of four randomized clinical trials involving 1,571 patients found that those with intensive blood pressure control had lower rates of functional independence after the procedure, though other complications showed no significant difference.
Background: Aneurysmal subdural hematoma (aSDH) is a rare complication of aneurysm rupture, affecting between 0.5 and 7.9% of patients with aneurysmal subarachnoid hemorrhage (aSAH).
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- This study aimed to assess how cerebral microbleeds (CMBs) affect outcomes for stroke patients undergoing endovascular thrombectomy (EVT), focusing on functional independence and safety.
- Using a systematic review approach, researchers analyzed four studies with 1,514 patients and found that the presence of CMBs significantly reduced the chances of achieving positive functional outcomes after EVT.
- However, CMBs had no effect on successful revascularization rates, mortality, or the occurrence of various hemorrhagic complications, indicating a specific impact of CMBs on functional recovery rather than overall safety.
Background And Purpose: New studies have shown that endovascular thrombectomy (EVT) is safe and effective for acute ischemic stroke (AIS) patients with large ischemic areas. The aim of our study is to conduct a living systematic review and meta-analysis of randomized trials comparing EVT versus medical management only.
Methods: We searched MEDLINE, Embase, and the Cochrane Library to identify randomized controlled trials (RCTs) comparing EVT versus medical management alone in AIS patients with large ischemic regions.
Article Synopsis
- Endovascular thrombectomy (EVT) is the primary treatment for acute ischemic stroke due to large vessel occlusion, but only about one-third of patients achieve good outcomes, partly due to the "no-reflow" phenomenon affecting blood circulation.
- A meta-analysis was conducted to evaluate the effectiveness of combining EVT with intra-arterial (IA) tissue plasminogen activator (tPA) in improving patient outcomes.
- The analysis revealed no significant differences in successful recanalization, functional independence, or risk of symptomatic intracranial hemorrhage between the EVT alone and the EVT plus IA tPA groups, indicating the need for further randomized controlled trials.
Background: Clinical trials used Cockcroft-Gault (CG) formula to calculate the estimated glomerular filtration rate (eGFR) in order to dose rivaroxaban for patients with atrial fibrillation (AF).
Objectives: The aim of this study is to evaluate rivaroxaban dosing appropriateness in patients with AF with or without renal impairment based on the CG formula and other formulae, including Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and the isotope dilution mass spectrometry (IDMS) traceable Modification of Diet in Renal Disease (MDRD) Study equation and the associated clinical outcomes.
Methodology: A retrospective cohort study conducted at Sultan Qaboos University Hospital (SQUH) from 1st January 2016 to 31st December 2020, included all adult patients (≥ 18 years) treated with rivaroxaban for AF and followed up for one year after starting the treatment.
Parkinson's disease (PD) is the fastest growing neurological disorder and one of the leading neurological causes of disability worldwide following stroke. An overall aging global population, as well as general changes in lifestyle associated with mass industrialization in the last century, may be linked to both increased incidence rates of PD and an increase in cumulative cardiovascular risk. Recent epidemiological studies show an increased risk of stroke, post-stroke complications, and subclinical ischemic insults in PD.
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- A case study reports a healthy male developing cerebral venous sinus thrombosis (CVST) after receiving the Ad26.COV2.S COVID-19 vaccine, presenting with symptoms like headache and vomiting.
- Neuroimaging revealed CVST, and despite an unremarkable hypercoagulability workup, the patient was treated with immunotherapy and anticoagulation, leading to symptom resolution.
- The article emphasizes the importance of early recognition and neuroimaging for severe headaches, especially after vaccination, to ensure better clinical outcomes.
Article Synopsis
- Mechanical thrombectomy (MT)
- is the standard treatment for large vessel occlusion (LVO), and its effectiveness might be influenced by whether it's combined with intravenous thrombolysis (IVT).
- A comprehensive meta-analysis
- involving seven clinical trials with 2317 patients found no significant differences in outcomes like successful recanalization, functional independence, symptomatic intracranial hemorrhage, or mortality between the two treatment approaches.
- The conclusion
- indicates that current evidence doesn't favor MT combined with IVT over MT alone for LVO, although more research is required to make better comparisons between the methods.
Background: Vasculitic neuropathies usually present acutely to subacutely, with an asymmetric pattern, involving multiple peripheral nerve territories. Drug-induced vasculitis is an often overlooked etiology of vasculitic neuropathy.
Methods: We present the first reported case of nitrofurantoin-associated and an illustrative case of minocycline-associated vasculitic neuropathy, with a review of the literature.
Background: Mechanical thrombectomy (MT) is the standard treatment for acute large vessel occlusion (LVO). Recurrent LVO can still occur in patients who already underwent MT for the first LVO. This study aimed to evaluate the efficacy of repeating MT for recurrent LVO.
View Article and Find Full Text PDFHigh neutrophil-lymphocyte ratio (NLR) is associated with poor survival in lung cancer. This study evaluates whether NLR is associated with baseline brain metastasis in stage IV non-small cell lung cancer (NSCLC). Medical records of stage IV NSCLC patients treated at King Hussein Cancer Center (Amman-Jordan) between 2006 and 2016 were reviewed.
View Article and Find Full Text PDFObjectives: Acyclovir is approved to treat herpes simplex virus (HSV) type 1, type 2 and varicella-zoster virus. It is mainly eliminated via the kidneys, for which drug crystals accumulation might lead to nephrotoxicity. This study aimed to determine the incidence, risk factors, preventive measures, and clinical outcomes of acyclovir induced-nephrotoxicity.
View Article and Find Full Text PDFCoronavirus disease 2019 (COVID-19) has been associated with multisystemic complications and thrombotic events including pulmonary embolism and deep venous thrombosis. Splenic rupture has been recently reported as a complication in patients with COVID-19, however, the number of cases is limited and the mechanism is still not clearly understood. We present a case of spontaneous splenic rupture secondary to COVID-19 disease.
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