Publications by authors named "Alaa Zeinhom"
Article Synopsis
- - Diabetes mellitus (DM) is a major global health issue, and current treatments often do not effectively prevent long-term complications, prompting interest in the use of mesenchymal stem/stromal cells (MSCs) for treatment.
- - MSCs have regenerative properties and can improve diabetes outcomes by enhancing insulin production, reducing insulin resistance, and protecting insulin-producing beta cells, with evidence from animal studies and clinical trials showing positive effects.
- - The review also highlights different strategies to optimize MSC treatment for diabetes, discusses the potential of MSC-derived extracellular vesicles, and addresses challenges like sourcing MSCs and the need for larger clinical trials to better understand their safety and efficacy.
The cytotoxicity of two tricarbonyl Mn(I) complexes of the general formula -[MnBr(CO)L] (L = quinoline-2-carboxaldehyde (A) and 8-amino quinoline (B)) towards triple negative breast cancer (MDA-MB-231) was reported. Complexes A and B released CO when exposed to 468 nm light. Compound B has a dose-dependent cytotoxicity, with half maximal inhibitory concentration values of 19.
View Article and Find Full Text PDFCarbon monoxide has recently emerged to promote tissue regeneration, enhance the innate immune system, and have anti-inflammatory and antibacterial properties. While the first generation Ru(II) carbonyl prodrugs (CORM-2 and CORM-3) displayed several beneficial biological effects, a search in the literature shows that little work has been done to address the drawbacks of CORM-2/-3, exploring other CO triggered methods for the next generation Ru(CO) based compounds and examining their valuable biological impact. We present a summary of most work related to Ru(II) carbon monoxide-releasing molecules, protein bioconjugation, and antibacterial and anti-inflammatory properties.
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