Publications by authors named "Alaa Oqalaa E Alibrahim"
Article Synopsis
- * The transmission of this disease requires freshwater snails and human contact with contaminated water, with no effective vaccines currently available despite ongoing research into potential candidates.
- * Praziquantel (PZQ) is a key medication for treating schistosomiasis, but its widespread use has raised concerns about drug resistance, while reinfection in high-risk areas and immature worms limit its effectiveness, highlighting the urgent need for a vaccine.
Modulating the HSP90 control over NFκB/NLRP3/Caspase-1 axis is a new therapeutic target in the management of liver fibrosis: Insights into the role of TAS-116 (Pimitespib).
Elsayed A Elmorsy Sameh Saber Rabab S Hamad Mustafa Ahmed Abdel-Reheim Eman Hassan Nadwa Alaa Oqalaa E Alibrahim
Life Sci
October 2024
Aberrant activation of the NLRP3 inflammasome is recognized to induce a chronic inflammatory response in the liver, ultimately leading to hepatic fibrosis. HSP90 is suggested to regulate NLRP3 activation and its downstream signaling. This study is the first to explore the potential therapeutic role of pimitespib in mitigating liver fibrosis in rats.
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