The prostaglandin EP4 receptor is a master regulator of the expression of PGE receptors following inflammatory activation in human monocytic cells.

Prostaglandin E (PGE) is responsible for inflammatory symptoms. However, PGE also suppresses pro-inflammatory cytokine production. There are at least 4 subtypes of PGE receptors, EP1-EP4, but it is unclear which of these specifically control cytokine production.