Drug toxicity prediction model based on enhanced graph neural network.

Prediction of drug toxicity remains a significant challenge and an essential process in drug discovery. Traditional machine learning algorithms struggle to capture the full scope of molecular structure features, limiting their effectiveness in toxicity prediction. Graph Neural Network offers a promising solution by effectively extracting drug features from their molecular graphs.

Assessing the impact of critical care training on pharmacy students in Egypt: a pre-post study.

Background: Transition to independent pharmacy practice is challenging. Undergraduate and postgraduate pharmacy students in low-to-middle-income countries (LMICs) currently receive minimal experiential learning in critical care.

Objective: To assess the critical care training course's impact on pharmacy students' knowledge, self-efficacy, and self-esteem, as well as their satisfaction with the course.

A multi-view feature representation for predicting drugs combination synergy based on ensemble and multi-task attention models.

This paper proposes a novel multi-view ensemble predictor model that is designed to address the challenge of determining synergistic drug combinations by predicting both the synergy score value values and synergy class label of drug combinations with cancer cell lines. The proposed methodology involves representing drug features through four distinct views: Simplified Molecular-Input Line-Entry System (SMILES) features, molecular graph features, fingerprint features, and drug-target features. On the other hand, cell line features are captured through four views: gene expression features, copy number features, mutation features, and proteomics features.

Utilizing Bayesian inference in accelerated testing models under constant stress via ordered ranked set sampling and hybrid censoring with practical validation.

This research investigates the application of the ordered ranked set sampling (ORSSA) procedure in constant-stress partially accelerated life-testing (CSPALTE). The study adopts the assumption that the lifespan of a specific item under operational stress follows a half-logistic probability distribution. Through Bayesian estimation methods, it concentrates on estimating the parameters, utilizing both asymmetric loss function and symmetric loss function.

A multi-task learning model for predicting drugs combination synergy by analyzing drug-drug interactions and integrated multi-view graph data.

This paper proposes a multi-task deep learning model for determining drug combination synergistic by simultaneously output synergy scores and synergy class labels. Initially, the two drugs are represented using a Simplified Molecular-Input Line-Entry (SMILE) system. Chemical structural features of the drugs are extracted from the SMILE using the RedKit package.

Reliability analysis of the triple modular redundancy system under step-partially accelerated life tests using Lomax distribution.

Triple modular redundancy (TMR) is a robust technique utilized in safety-critical applications to enhance fault-tolerance and reliability. This article focuses on estimating the distribution parameters of a TMR system under step-stress partially accelerated life tests, where each component included in the system follows a Lomax distribution. The study aims to analyze the system's reliability and mean residual lifetime based on the estimated parameters.

Duplex Hemodynamic Parameters of Both Superior and Inferior Thyroid Arteries in Evaluation of Thyroid Hyperfunction Disorders.

Background: Thyrotoxicosis may be caused by Graves' disease or destructive thyroiditis. Differentiation between causes of thyrotoxicosis is crucial as management will differ. Technetium (Tc)-pertechnetate thyroid scintigraphy is currently the gold standard for this purpose, however, is expensive and uses ionizing radiation.

Occurrence and clinical characteristics of occult hepatitis C virus infection in hemodialysis units at Ismailia, Egypt.

Background And Aims: Occult hepatitis C infection is defined as the presence of hepatitis C virus RNA in peripheral blood mononuclear cells (PBMC) ± hepatocytes in the absence of HCV-RNA in serum. It has been a lot of debate and controversy in recent years and not discussed well. This issue has not been discussed or investigated in Egypt, especially in patients on hemodialysis in Ismailia.

Surgical Non-Surgical Management of Obstructive Sleep-disordered Breathing in Children: A Meta-analysis.

Background: Obstructive sleep-disordered breathing (OSDB) is a term for several chronic conditions in which partial or complete cessation of breathing occurs many times throughout the night, resulting in fatigue or daytime sleepiness that interferes with a person's functions and reduces the quality of life.

Objective: Comparing the effectiveness of surgical non-surgical treatment of OSDB in children in clinical trials through a meta-analysis study.

Patients And Methods: A number of available studies and abstracts concerning the surgical non-surgical treatment of OSDB in children were identified through a comprehensive search of electronic databases.

Prevalence of gastrointestinal nematodes, parasite control practices and anthelmintic resistance patterns in a working horse population in Egypt.

Background: Anthelmintic resistance is commonly reported in horse populations in developed countries, but evidence in some working horse populations is either lacking or inconclusive.

Objectives: To estimate prevalence of GI nematode infections in working horses in Egypt and to evaluate strongyle resistance to ivermectin, doramectin and fenbendazole.

Study Design: Cross-sectional study.

Therapeutic efficacy of olfactory stem cells in rotenone induced Parkinsonism in adult male albino rats.

Background: Olfactory stem cells (OSCs) are found in the olfactory mucosa and olfactory bulb and have the capacity to proliferate and differentiate along multiple tissue lineages. Rotenone; widely used insecticide has a neurodegenerative effect on the dopaminergic cells of substantia nigra (SN) of midbrain producing Parkinsonism. The aim of this study is to isolate rat OSCs from olfactory mucosa and olfactory bulb, culture these OSCs in suitable medium to allow for their proliferation to be used in the treatment of Parkinsonism induced by rotenone.

Clinical audit of ectopic pregnancy.

Objective: The aim of this study was to determine the risk factors of ectopic pregnancy in cases presented to the Woman's Health Hospital (WHH) in Assuit University, and to perform clinical audit on strategies for management of ectopic pregnancy in the WHH.

Methods: This descriptive hospital based study was conducted at the Woman's Health Hospital (WHH) of Assuit University (Egypt). There were 210 patients who were admitted to the WHH with the diagnosis of ectopic pregnancy in the period between February 1, 2015 through the end of October 2015.

Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome.

The RASopathies constitute a family of autosomal-dominant disorders whose major features include facial dysmorphism, cardiac defects, reduced postnatal growth, variable cognitive deficits, ectodermal and skeletal anomalies, and susceptibility to certain malignancies. Noonan syndrome (NS), the commonest RASopathy, is genetically heterogeneous and caused by functional dysregulation of signal transducers and regulatory proteins with roles in the RAS/extracellular signal-regulated kinase (ERK) signal transduction pathway. Mutations in known disease genes account for approximately 80% of affected individuals.

Insulin resistance and prediabetes in hepatitis C virus patients.

Background: Egypt has the highest prevalence of hepatitis C virus (HCV) infection in the world and is facing an epidemic of type 2 diabetes mellitus. The objective of this study was to assess the prevalence of insulin resistance (IR) and prediabetes among HCV patients.

Methods: A cross-sectional case-control study was performed on 188 HCV patients admitted to the Internal Medicine Department in Menoufia University Hospital during the period from May to August 2014.

The role of anti-Mullerian and inhibin B hormones in the evaluation of 46,XY disorders of sex development.

Objective: To assess the sensitivity and specificity of anti-Mullerian hormone (AMH) and inhibin B for diagnosis of 46,XY disorders of sex development (DSD).

Patients And Methods: The study included 43 patients of 46,XY DSD and compared them with 43 healthy, male, age matched controls. All patients underwent karyotyping, assessment of testosterone, dihydrotestosterone (DHT) and Δ4-androstendione (Δ4A) basal and after human chorionic gonadotropin (HCG) testing.

Novel mutations of the nucleophosmin (NPM-1) gene in Egyptian patients with acute myeloid leukemia: a pilot study.

Unlabelled: Mutations of the nucleophosmin (NPM-1) gene have been reported in 50-60% of acute myeloid leukemia (AML) patients with normal karyotype. This work was designed to study the prevalence and nature of NPM1 gene mutations in a group of Egyptian patients with AML to get an idea about the profile of NPM1 gene mutations in our society. In 45 previously untreated patients with de novo AML, peripheral blood and/or bone marrow samples from all patients were subjected to microscopic morphologic examination, cytochemical analysis, immunophenotyping and karyotyping.

Renal duplex doppler ultrasonography in patients with recurrent urinary tract infection.

Renal hemodynamics were studied using duplex Doppler ultrasonography in forty (33 females and 7 males; mean age: 12.1 +/- 5.3 years) normotensive patients with recurrent urinary tract infection and with no evidence of obstructive uropathy and age matched control group of 24 healthy children and adolescents.

INF-gamma, IL-5 and IgE profiles in chronic schistosomiasis mansoni Egyptian patients with or without hepatitis C infection.

The immune response against clinical forms of chronic schistosomiasis mansoni patients with or without HCV infection was evaluated by assays the serum levels of IFN-gamma and IL-5 for estimate the cell mediated immunity and IgE level to estimate the humoral immunity. This study included three patient groups. G.