LC-qTOF-MS/MS phytochemical profiling of Tabebuia impetiginosa (Mart. Ex DC.) Standl. leaf and assessment of its neuroprotective potential in rats.

Ethnopharmacological Relevance: Tabebuia impetiginosa (Bignoniaceae) was traditionally used for memory enhancement and central nervous system (CNS) stimulation.

Aim Of The Study: This study aims to create a metabolic profile of the ethyl acetate fraction of T. impetiginosa (TEF) and investigate for the first time its neuroprotective potential on cyclophosphamide (CP)-induced chemobrain, validating its traditional use.

Involvement of Autophagic Machinery in Neuropathogenesis: Targeting and Relevant Methods of Detection.

The exquisite balance between cellular prosurvival and death pathways is extremely necessary for homeostasis. Different forms of programmed cell death have been widely studied and reported such as apoptosis, necroptosis, pyroptosis, and autophagy. Autophagy is a catabolic process important for normal cellular functioning.

Lactoferrin ameliorates carfilzomib-induced renal and pulmonary deficits: Insights to the inflammasome NLRP3/NF-κB and PI3K/Akt/GSK-3β/MAPK axes.

Aims: Carfilzomib, an irreversible proteasome inhibitor, has been increasingly used to treat multiple myeloma worldwide. However, case studies showed its treatment has been associated with cardiac, renal, and pulmonary deleterious effects. Lactoferrin is an iron-binding glycoprotein present in milk.

Anticancer role of mango (Mangifera indica L.) peel and seed kernel extracts against 7,12- dimethylbenz[a]anthracene-induced mammary carcinogenesis in female rats.

Breast cancer is the second leading cause of cancer death among women. The present study is an effort to reveal the antiproliferative and antioxidant actions of mango seed kernel extract (KE), peel extract (PE), and their combination (KEPE) on mammary tumors induced by 7,12 dimethylbenz[a]anthracene (DMBA). Seven groups of adult female Sprague-Dawley rats were prepared, including C: (control), DMBA: (rats were administered with DMBA), (DMBA-KE), (DMBA-PE), and (DMBA-KEPE): rats were administered with DMBA and then treated with KE, PE, and (both KE and PE), respectively, (KE) and (PE): rats were administered with KE and PE, separately.

The diuretic amiloride attenuates doxorubicin-induced chemobrain in rats: Behavioral and mechanistic study.

Cognitive impairment or "chemobrain" is a troublesome adverse effect which had been increasingly reported by cancer patients after doxorubicin (DOX) chemotherapy. Notably, Hypertension, a very common comorbidity in cancer patients, could pose a greater risk for negative cognitive outcomes. Amiloride (AML) is an antihypertensive, potassium-sparing diuretic that has been proven to be neuroprotective in different experimental models; this can be attributed to its ability to inhibit different ion transporters such as NaH exchanger (NHE), which upon excessive activation can result in intracellular cationic overload, followed by oxidative damage and cellular death.

Modeling climatic effect on physiochemical parameters and microorganisms of Stabilization Pond Performance.

The present study was carried out to evaluate the relationship between physiochemical parameters, microorganisms, wastewater and climate in Stabilization Pond Performance. This study performed as a post-treatment after the secondary wastewater treatment using extended aeration in Rashid city, Egypt. The model of the extended aeration as secondary wastewater treatment was developed based on the combination with lagoon after the secondary sedimentation basin.

Spectral, thermal studies and biological activity of pyrazinamide complexes.

Synthesis and spectrothermal characterization of new fabricated pyrazinamide complexes with metal [Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II)] salts are reported. The structural chemistry of these complexes is achieved via elemental analysis, spectral (UV, visible, and IR), thermal (DTA and TGA) as well as magnetic susceptibility. In these new octahedral complexes (Zn complex is tetrahedral), pyrazinamide acts as a bidentate ligand.

Rifampicin ameliorates lithium-pilocarpine-induced seizures, consequent hippocampal damage and memory deficit in rats: Impact on oxidative, inflammatory and apoptotic machineries.

Epilepsy is one of the serious neurological sequelae of bacterial meningitis. Rifampicin, the well-known broad spectrum antibiotic, is clinically used for chemoprophylaxis of meningitis. Besides its antibiotic effects, rifampicin has been proven to be an effective neuroprotective candidate in various experimental models of neurological diseases.

Synthesis, spectroscopic, biological activity and thermal characterization of ceftazidime with transition metals.

Synthesis, physicochemical characterization and thermal analysis of ceftazidime complexes with transition metals (Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II)) were discussed. It's obtained that ceftazidime act as bidentate ligand. From magnetic measurement and spectral data, octahedral structures were proposed for all complexes except for cobalt, nickel and mercury had tetrahedral structural.

Synthesis, spectral, computational and thermal analysis studies of metallocefotaxime antibiotics.

Cefotaxime metal complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II) and two mixed metals complexes of (Fe,Cu) and (Fe,Ni) were synthesized and characterized by elemental analysis, IR, electronic spectra, magnetic susceptibility and ESR spectra. The studies proved that cefotaxime may act as mono, bi, tri and tetra-dentate ligand through oxygen atoms of lactam carbonyl, carboxylic or amide carbonyl groups and nitrogen atom of thiazole ring. From the magnetic measurements and electronic spectral data, octahedral structures were proposed for all complexes.

Solvation and equilibrium studies of some compounds containing azo and nitroso chromophores.

The stability studies of biologically active phenylazo-dinitroso resorsinol and o-hydroxy phenyl azo-dinitroso resorsinol compounds were studied. The dissociation constants and the thermodynamic parameters of dissociation were evaluated and determined potentiometrically. Regression analysis is applied for correlating the different parameters by using the SPSS program.

Spectroscopic studies on gallic acid and its azo derivatives and their iron(III) complexes.

Azo gallic derivatives and their iron(III) complexes were synthesized and characterized. The stereochemistry and the mode of bonding of the complexes were achieved based on elemental analysis, UV-Vis and IR. The thermal behaviors of the complexes were studied.

Spectral, coordination and thermal properties of 5-arylidene thiobarbituric acids.

Synthesis of 5-arylidine thiobarbituric acids containing different functional groups with variable electronic characters were described and their Co(2+), Ni(2+) and Cu(2+) complexes. The stereochemistry and mode of bonding of 5-(substituted benzylidine)-2-TBA complexes were achieved based on elemental analysis, spectral (UV-VIS, IR, (1)H NMR, MS), magnetic susceptibility and conductivity measurements. The ligands were of bidentate and tridentate bonding through S, N and O of pyrimidine nucleolus.

Solvatochromic behavior of the electronic absorption spectra of gallic acid and some of its azo derivatives.

The electronic absorption spectra of gallic acid and its azo derivatives have been studied in various solvents of different polarities. Multiple regression techniques were applied to calculate the regression and correlation coefficients based on an equation that relates the wavenumbers of the absorption band maxima (υ(max)(-)) to the solvent parameters; refractive index (n), dielectric constant (D), empirical Kamlet-Taft solvent parameters, π*(dipolarity/polarizability), α (solvent hydrogen-bond donor acidity) and β (solvent hydrogen-bond acceptor basicity). The fitting coefficient obtained from this analysis allows estimating the contribution of each type of interactions relative to total spectral shifts in solution.

Synthesis, computational, spectroscopic, thermal and antimicrobial activity studies on some metal-urate complexes.

New sixteen uric acid metal complexes of different stoichiometry, stereo-chemistries and modes of interactions were synthesized using different metals Cr, Mn, Fe, Co, Ni, Cu, Cd, UO(2), Na and K. The synthesized complexes were characterized by elemental analysis, spectral (IR, UV-Vis and ESR) methods, thermal analysis (TG, DTA and DSC) and magnetic susceptibility studies. Molecular modeling calculations were used to characterize the ligation sites of the free ligand.

Solvatochromaticity and pH dependence of the electronic absorption spectra of some purines and pyrimidines and their metal complexes.

The solvatochromic responses of uric acid (Ua), 6-amino-2-thiouracil (ATU) and a series of their complexes dissolved in ten solvents of different polarity have been measured. The solvent-dependent UV/Vis spectroscopic absorption maxima, λ(max), are assigned to the corresponding electronic transitions and analyzed using SPSS program, regression analysis and Kamlet and Taft methods. The observed solvatochromism is discussed using various solute-solvent interaction mechanisms.

Synthesis, spectral, thermal and antimicrobial studies of some new tri metallic biologically active ceftriaxone complexes.

Iron, cobalt, nickel and copper complexes of ceftriaxone were prepared in 1:3 ligand:metal ratio to examine the ligating properties of the different moieties of the drug. The complexes were found to have high percentages of coordinated water molecules. The modes of bonding were discussed depending on the infrared spectral absorption peaks of the different allowed vibrations.

Dielectric spectroscopy of some heteronuclear amino alcohol complexes.

The temperature dependent dielectric spectroscopic properties of two heteronuclear complexes of monoethanolamine (MEA) at a wide temperature range (303-413 K) were investigated by impedance spectroscopy, in the frequency range from 100 Hz to 100 kHz. The frequency dependence of the impedance spectra plotted in the complex plane shows semi-circles. The Cole-Cole diagrams have been used to determine the molecular relaxation time, tau.

Solvent and substituent effects on spectroscopical changes of some diazoaminobenzene derivatives.

A series of diazoaminobenzene derivatives (seven) in which the substituents have a wide range of electronic characters are set out to understand the involvement of the substituent identity in controlling the changes in their electronic absorption spectra. The interactions between the diazoamino group and the different groups account for some spectral shifts. The UV-vis spectrum of each compound is measured in several solvents with wide variations of solvent polarity parameters to examine the role of the chemistry of the solvent in these spectroscopical changes.

Dielectric relaxation spectroscopy of heteronuclear cobalt(II)-copper(II) complex of 1-phenyl-3-methyl-5-pyrazolone.

A bright green CoCu(PMP)(OH)2(H2O)2 complex was synthesized. Its structure was elucidated and characterized by different spectroscopic techniques. Both cobalt and copper atoms attain tetrahedral geometry.

Solvatochromic behavior of the electronic absorption spectra of some azo derivatives of amino pyridines.

The electronic absorption spectra of a series of the entitled eight compounds containing groups with variable electronic characters were recorded. The solvents were selected to cover a wide range of parameters (refractive index, dielectric constant and hydrogen bonding capacity). The electronic transitions are assigned and the solvent induced spectral shifts have been analyzed in relation to the different solute-solvent interaction mechanisms using computational chemistry.

Spectroscopic studies on some azo compounds and their cobalt, copper and nickel complexes.

Synthesis and characterization of [o-carboxy phenylazo] moiety of barbituric acid, thiobarbituric acid, thiouracil, citrazinic acid, and disodium chromotropate and their complexes derived from cobalt (II), nickel (II), and copper (II) salts were done. The stereochemistry and the mode of bonding of the complexes were achieved based on elemental analysis, NMR, UV-Vis, IR and ESR. The dissociation constants of the free azo ligands are evaluated by spectrophotometric methods.

Complexing properties of nucleic-acid constituents adenine and guanine complexes.

Cobalt, nickel and copper complexes of adenine and guanine, as nucleic-acid constituents, were prepared. The adenine and guanine complexes are of tetrahedral and octahedral geometries, respectively. All are of high spin nature.

Effect of cadmium and zinc ethanolamine complexes on rat brain monoamine oxidase-B activity in vitro.

Monoamine oxidase-B (MAO-B) from rat brain was inhibited strongly by the prepared cadmium and zinc ethanolamine complexes obtained from their sulphate and chloride salts. The inhibition of MAO-B by these complexes was time-dependent and fully reversible after dilution and sedimentation. In vitro, the cadmium ethanolamine complexes were more potent at inhibiting MAO-B than the zinc complexes.