Publications by authors named "Alaa Alibrahim"
Article Synopsis
- Drug resistance (DR) to antituberculosis drugs is increasingly problematic in controlling tuberculosis (TB) globally, particularly in Gulf Cooperation Council (GCC) countries, where TB is a significant public health concern.
- This systematic review analyzed peer-reviewed articles published since 2014 to assess the prevalence and risk factors of drug-resistant TB (DR-TB) in the GCC, identifying isoniazid monoresistance as the most common form and highlighting factors such as diabetes, previous TB treatment, and expatriate status as significant risks.
- The review stresses the need for collaboration among stakeholders to develop evidence-based interventions and highlights the importance of ongoing research and surveillance to manage and mitigate the impact of DR-TB on public health in the
Article Synopsis
- * The transmission of this disease requires freshwater snails and human contact with contaminated water, with no effective vaccines currently available despite ongoing research into potential candidates.
- * Praziquantel (PZQ) is a key medication for treating schistosomiasis, but its widespread use has raised concerns about drug resistance, while reinfection in high-risk areas and immature worms limit its effectiveness, highlighting the urgent need for a vaccine.
Modulating the HSP90 control over NFκB/NLRP3/Caspase-1 axis is a new therapeutic target in the management of liver fibrosis: Insights into the role of TAS-116 (Pimitespib).
Life Sci
October 2024
Aberrant activation of the NLRP3 inflammasome is recognized to induce a chronic inflammatory response in the liver, ultimately leading to hepatic fibrosis. HSP90 is suggested to regulate NLRP3 activation and its downstream signaling. This study is the first to explore the potential therapeutic role of pimitespib in mitigating liver fibrosis in rats.
View Article and Find Full Text PDFBackground: Autologous flaps may have superior outcomes when compared to implant breast reconstruction in patients with obesity. To date, no published review has illustrated the superiority of autologous to implant-based reconstruction in this study group in terms of aesthetics outcomes and surgical complications.
Methods: A systematic search was conducted on PubMed, Cochrane, Google Scholar, and Embase from inception to December 31, 2020.