Publications by authors named "Alaa Abd Elsayed"

Objectives: Past studies have shown the efficacy of spinal targeted drug delivery (TDD) in pain relief, reduction in opioid use, and cost-effectiveness in long-term management of complex chronic pain. We conducted a survey to determine treatment variables associated with patient satisfaction.

Materials And Methods: Patients in a single pain clinic who were implanted with Medtronic pain pumps to relieve intractable pain were identified from our electronic health record.

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Background: The analysis of epidural procedure utilization has revealed several notable trends over recent years. Utilization increased significantly until 2004, then rose minimally until 2011, followed by gradual declines up to 2019 in the Medicare population. The COVID-19 pandemic led to a marked 19% decline in usage from 2019 to 2020.

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Background: The use of facet joint interventions for spinal pain management experienced rapid growth between 2000 and 2010, with an annual increase of 14.2%. However, this trend slowed significantly from 2010 to 2019, with a reduced growth rate of just 2.

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Remote Patient Monitoring (RPM) stands as a pivotal advancement in patient-centered care, offering substantial improvements in the diagnosis, management, and outcomes of chronic conditions. Through the utilization of advanced digital technologies, RPM facilitates the real-time collection and transmission of critical health data, enabling clinicians to make prompt, informed decisions that enhance patient safety and care, particularly within home environments. This narrative review synthesizes evidence from peer-reviewed studies to evaluate the transformative role of RPM, particularly its integration with Artificial Intelligence (AI), in managing chronic conditions such as heart failure, diabetes, and chronic pain.

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Background: Dorsal root ganglion stimulation (DRGS) is an established method for treating persistent and severe pain conditions. However, performing DRGS has significant challenges. Current DRGS systems are expensive, hindering accessibility for many patients and health care systems.

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Background: Numerous studies have highlighted the escalating costs associated with managing low back and neck pain, as well as other musculoskeletal disorders. In the past, there was a notable increase in the use of interventional techniques to address these disorders. However, the COVID-19 pandemic disrupted various chronic pain treatment approaches, including interventional procedures and opioid use, following a broader trend of reduced healthcare services.

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Unlabelled: Chronic low back pain (CLBP) negatively impacts quality of life and contributes to a significant economic burden. One conservative management strategy for CLBP is lumbar back bracing. Despite the benefits of back bracing for improving pain and function, there remains hesitance to use the therapy long term due to unfounded fear related to muscle weakness, deconditioning, or joint contracture.

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Pain serves as a vital innate defense mechanism that can significantly impact an individual's quality of life. Understanding the physiological effects of pain well plays an important role in developing novel pain treatments. Nociceptor neurons play a key role in pain and inflammation.

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Background: Peripheral nerve stimulation (PNS) has been used for over 50 years to treat chronic pain by delivering electrical pulses through small electrodes placed near targeted peripheral nerves those outside the brain and spinal cord. Early PNS systems often required invasive neurosurgical procedures. However, since 2015, the Food and Drug Administration (FDA) approved percutaneously implanted PNS leads and neurostimulators  offering a much less invasive, non-opioid option for managing recalcitrant chronic pain.

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Background: This manuscript presents the challenges of treating various forms of headaches and the potential of interventional techniques targeting the greater occipital nerve (GON) to alleviate the burden on patients. Occipital neuralgia, characterized by stabbing or shooting pain in the base of the skull, is often associated with primary, cervicogenic, or migraine headaches. While occipital nerve blocks offer temporary relief, durable treatment options are limited.

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Article Synopsis
  • * EVs and exosomes, tiny structures released by cells, show promise in treating conditions like osteoarthritis and intervertebral disc disease by reducing inflammation and promoting tissue repair in animal models.
  • * While clinical use of EVs and exosomes for chronic pain management is still developing, ongoing research and clinical trials suggest they have substantial potential for future therapies.
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Introduction: Knee osteoarthritis (OA) is a highly prevalent and debilitating condition with significant emotional and economic impacts. Current treatment options may only provide temporary pain relief and are not regenerative, thus the progression of knee OA is not deterred and total knee arthroplasty is inevitable. Injection therapies with orthobiologics possess regenerative potential and are an emerging treatment option.

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The opioid epidemic continues to have a staggering impact on millions of individuals and families across all socioeconomic levels and communities. Recent studies suggest high numbers of patients presenting for surgery with reported opioid misuse and/or opioid use disorder (OUD). Anesthesiologists often lack basic education to treat patients suffering with OUD or patients in recovery from this treatable disease.

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Introduction: Chronic pain is a personal experience influenced by multiple biopsychosocial factors. Using a pain intensity measure alone to assess the effectiveness of a chronic pain intervention fails to fully evaluate its impact on the multifaceted chronic pain experience. The holistic minimal clinically important difference (MCID) is a composite outcome developed to provide a comprehensive assessment of chronic pain in response to intervention, across 5 outcome domains: pain intensity, health-related quality of life, sleep quality, physical, and emotional function.

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Article Synopsis
  • Current guidelines suggest a personalized and combination approach to pain management, emphasizing the use of both drug and non-drug therapies, with a focus on reducing chronic pain risks in acute pain cases like surgery or trauma.
  • Auricular vagus nerve stimulation (aVNS) is explored as a potentially effective non-drug therapy for managing both chronic and acute pain, with this study aiming to assess its clinical efficacy and safety.
  • The analysis included 23 studies on chronic pain, 12 on acute postoperative pain, and 7 on experimental acute pain, finding significant pain reduction in chronic conditions through aVNS compared to sham treatments, indicating its potential effectiveness.
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Radiofrequency ablation (RFA) is a neuromodulation technique that uses electrocautery to damage nerves with thermal energy and interrupt nociception and has primarily been used to treat patients with chronic back pain. While the use of RFA to modulate neuronal innervation of cervical and lumbar facet joints is well studied, research on the applications of RFA to target the thoracic spine is limited despite these facet joints accounting for pain in over 25% of patients with chronic mid-back and upper-back pain. The purpose of this paper is thus to describe RFA and its utilization in the thoracic spine for chronic back pain.

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Article Synopsis
  • Sacroiliac joint (SIJ) dysfunction is a painful condition affecting the lower back, hips, and legs, often resulting from injury or degeneration, and is difficult to diagnose accurately without specific procedures.*
  • A study was conducted to evaluate the effectiveness of minimally invasive posterior SIJ fusion using allograft, analyzing data on pain levels, surgical times, and medication usage in patients diagnosed with SIJ dysfunction.*
  • Results showed significant reductions in pain scores and opioid medication usage over 12 months following the procedure, indicating promising short-term relief for patients suffering from SIJ dysfunction.*
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Article Synopsis
  • The increasing use of interventional techniques in chronic pain patients on anticoagulant and antiplatelet therapy poses challenges in balancing the bleeding risk from these medications and the thrombosis risk from discontinuation.
  • Guidelines have been developed through a literature review and expert consensus to help assess and manage the risks of bleeding and thrombosis during interventional procedures for these patients.
  • These guidelines provide a framework for healthcare professionals to make informed decisions regarding the continuation or temporary suspension of anticoagulant and antiplatelet therapy in the context of interventional pain management.
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