Common Statin Intolerance Variants in and Show Synergistic Effects on Statin Response: An Observational Study Using Electronic Health Records.

Statin intolerance impacts approximately 10% of statin users, with side effects ranging from mild myalgia to extreme intolerance resulting in myopathy and rhabdomyolysis. Statin intolerance results in poor adherence to therapy and can impact statin efficacy. Many genetic variants are associated with statin intolerance.