The study investigates the relationship between histologic grade and estrogen receptor (ER) status in ductal carcinoma in situ (DCIS) patients who have positive surgical margins after breast-conserving surgery (BCS).
A total of 615 female patients were reviewed, with findings showing that larger tumor size is a key risk factor for positive margins, while negative ER status also significantly correlates with this outcome.
The results suggest that understanding these factors can guide changes in surgical practices to lower the risk of positive margins, especially in patients with large, ER-negative DCIS.
Sentinel lymph node biopsy is essential for tailoring treatment in cutaneous melanoma, and a study compared the effectiveness of two identification methods: radiotracer injection and indocyanine green (ICG) fluorescent dye.
The study involved 54 patients, with both techniques accurately identifying the sentinel node in 52 out of 54 cases, demonstrating that they consistently mapped to the same nodes.
Results showed a similar cancer involvement rate of 19.2% for both methods, with no significant differences in recurrence or survival, suggesting ICG could be a reliable and potentially more cost-effective alternative to the traditional radiotracer method.