Publications by authors named "Ala Foremny"

Article Synopsis
  • Idiopathic hypereosinophilic syndrome (IHES) causes long-term high eosinophil levels, leading to organ damage, particularly the heart, affecting around 60% of patients and increasing mortality risk.
  • A case study involves a 33-year-old male who presented with severe respiratory symptoms and abnormal heart tests, ultimately diagnosed with heart issues linked to IHES.
  • The patient received early corticosteroid treatment, which normalized his eosinophil count and resulted in moderate cardiac improvement, and he is currently stable on prednisone.
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Article Synopsis
  • Idiopathic pulmonary arterial hypertension (IPAH) is a severe condition marked by changes in pulmonary blood vessels, leading to right-heart failure and potentially premature death, primarily caused by mutations in the BMPR-2 gene.
  • The study aimed to analyze the levels of TGF-beta1 and its receptors in IPAH patients compared with those suffering from Eisenmenger's syndrome (ES) and healthy controls, observing notable differences in gene expression across these groups.
  • Results showed that ES patients had significantly higher TGF-beta1 receptor gene expression, with various correlations identified between TGF-beta1 and receptors across different patient groups, hinting at complex interactions affecting disease progression.
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Primary pulmonary arterial hypertension (PPH) is a rare disease of undetermined origin and fatal prognosis. A better prognosis is associated with at least 20% reduction of either pulmonary artery pressure or pulmonary vascular resistance ("responders") in acute vasodilatory trials. Prostacycline (PGI2) or nitric oxide (NO) administration promises valuable results.

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