Publications by authors named "AlGhamdi K"
Purpose: Hyperhidrosis (HH) is characterized by excessive sweating, which can significantly affect quality of life. The Hyperhidrosis Quality of Life Index (HidroQoL©) is the latest tool that has been developed and validated for assessing the quality of life of patients with HH. Because of the absence of an Arabic version of the HidroQoL©, this research aimed to create, validate, and adapt the HidroQoL© into Arabic.
View Article and Find Full Text PDFThis study addresses the pervasive issue of particulate matter (PM) emission in urban areas, proposing a better approach using scanning electron microscope (SEM) techniques to identify plant species effective in airborne PM removal. Conducted in Bilaspur city, the research strategically selected six plant species across four distinct sites and applied the SEM-Image J method for analysis, yielding significant insights, especially in the respirable PM range. Among the tested plant species, Senna Siamea and Dalbergia Sissoo emerged as consistent and standout performers, displaying the highest PM removal efficiency across all sites.
View Article and Find Full Text PDFCommunity pharmacies have expanded to include new services such as health screenings and medication reviews. However, developing and implementing new applications tends to be challenging and entails comprehensive planning by multiple stakeholders. This qualitative study explores stakeholders' perspectives of these new services and identifies perceived barriers or facilitators for implementing practice changes.
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- The pomegranate peel is rich in phenolic compounds, which have medicinal and commercial value, but their concentrations and biological activities during different ripening stages are not well understood.
- Extracts from pomegranate peels at various growth stages (40, 80, and 120 days) were tested, with stage 2 and stage 3 showing strong antimicrobial effects.
- Notably, the stage 2 extract was most effective against lung, breast, and liver cancer cells, and further analysis confirmed γ-Sitosterol as a key compound responsible for its antimicrobial and cytotoxic properties, although more testing is required to confirm these findings.
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- Intraventricular glioblastoma multiforme (GBM) is an uncommon brain tumor, especially in infants, with this case detailing a 54-day-old baby who presented with symptoms of increased head size and vomiting.
- The infant underwent surgery to remove the tumor, which was confirmed to be a pediatric-type glioblastoma through histopathological examination.
- Over a 10-year follow-up, the child experienced developmental delays and seizures but showed no signs of tumor recurrence, indicating a rare instance of long-term survival after this aggressive cancer.
Background: Amblyopia, or "lazy eye," is a visual disorder that often goes undiagnosed, especially in its early stages. Early detection and treatment are critical to preventing long-term visual impairment. This study aimed to assess the awareness of amblyopia among the population of Jazan, Saudi Arabia.
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- * This study examined how oxytocin (OXT) affects melanocyte functions, finding that OXT boosts the proliferation and migration of human melanocytes in a dose-dependent manner.
- * OXT also enhances the expression of proteins linked to melanin production and increases overall melanin output, suggesting that the OXT system could be a promising target for treating skin pigmentary disorders.
Inflammatory Bowel Diseases (IBD), which encompass ulcerative colitis (UC) and Crohn's disease (CD), are characterized by chronic inflammation and tissue damage of the gastrointestinal tract. This study aimed to uncover novel disease-gene signatures, dysregulated pathways, and the immune cell infiltration landscape of inflamed tissues. Eight publicly available transcriptomic datasets, including inflamed and non-inflamed tissues from CD and UC patients were analyzed.
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- Solitary fibrous tumors (SFTs) make up a small percentage (3.7%) of soft-tissue sarcomas, with a low annual incidence rate, and primarily affect the central nervous system, notably the brain more than the spine.
- A 46-year-old woman experienced sciatica for 18 months and was found to have a dumbbell-shaped tumor at the L4-L5 level causing nerve compression, diagnosed through an MRI.
- She underwent a successful surgical procedure, a left hemi-laminectomy, and the tumor was confirmed post-surgery to be a WHO Grade I hemangiopericytoma, indicating a low-grade tumor.
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- Over the past 20 years, endoscopic endonasal skull base surgery (EESBS) has significantly improved treatment for skull base tumors, but complications like cerebrospinal fluid (CSF) leaks still present challenges, with an average incidence of 8.9%.
- This study analyzed 51 patients who underwent EESBS between 2016 and 2022 in Saudi Arabia, focusing on patient demographics, tumor characteristics, and postoperative outcomes.
- Findings indicated a 9.8% incidence of CSF leaks, with a notable correlation between preoperative headaches and leaks, suggesting that factors like hypertension and prior neurological issues might increase risk.
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- Luteolin (LUT) is a bioactive compound noted for its anticancer properties, and the study explores creating a combined delivery system with doxorubicin (DOX), an effective chemotherapy drug, using polymeric micelles (PMs).
- PMs were formulated with specific ratios of Lut, DOX, and various stabilizers like Poloxamer and Vitamin E, achieving optimized sizes and characteristics confirmed by particle size analysis, transmission electron microscopy, and spectroscopy techniques.
- Cytotoxicity tests on cancer cell lines showed the effectiveness of the PM formulations, with successful development demonstrated by controlled droplet sizes and stable zeta potentials.
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- BTBGD is a rare genetic disorder caused by mutations in the SLC19A3 gene, leading to severe neurological symptoms like confusion, seizures, and disabilities.
- Diagnosis is challenging due to the disease's rarity and varied symptoms, with current treatment involving thiamine and biotin supplementation, although long-term effectiveness is still unclear.
- Researchers have created induced pluripotent stem cell (iPSC) lines from a BTBGD patient, which can help study the disease's mechanisms and potentially lead to new treatments.
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- Brucellosis is a widespread zoonotic disease that predominantly affects spinal health, yet there's limited information on the best antibiotic treatments for spinal brucellosis.
- A retrospective study conducted over 11 years in Makkah, Saudi Arabia, analyzed the treatment outcomes of 35 spinal brucellosis patients, focusing on their age, symptoms, and antibiotic regimens used.
- The most common treatment regimen was a combination of streptomycin, doxycycline, and rifampicin, with a low failure rate; however, some patients required surgical intervention, indicating the seriousness of the condition.
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- A study at Al-Baha University explored the link between smartphone addiction and musculoskeletal pain among students.
- 72% of participants reported smartphone addiction, with a significant correlation found between addiction and lower back pain (p=0.004).
- Clinical-year students showed a higher risk for neck pain compared to those in internships, emphasizing the need for awareness regarding the health risks of excessive smartphone use.
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- The study created a tool to evaluate surgical videos, addressing gaps in current evaluation methods that focus mainly on written content.
- The tool was tested with expert feedback, resulting in 23 criteria assessing educational value, accuracy, and clarity in surgical demonstrations.
- Analysis of 25 YouTube videos on elliptical excision revealed that while their quality was fair to good, there's a need for improved video production to enhance educational value.
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- The REPLENISH trial aims to determine if higher protein supplementation in critically ill patients improves 90-day survival rates compared to moderate protein intake.
- The study will involve randomizing 2,502 mechanically ventilated patients to receive either higher (2-2.4 g/kg/day) or moderate (0.8-1.2 g/kg/day) protein levels, with a focus on all-cause mortality and quality of life outcomes.
- The research has received ethical approval and will share findings through journals and conferences to influence future clinical practices.
Infected wounds pose a significant challenge in healthcare, requiring innovative therapeutic strategies. Therefore, there is a critical need for innovative pharmaceutical materials to improve wound healing and combat bacterial growth. This study examined the efficacy of azithromycin-loaded silver nanoparticles (AZM-AgNPs) in treating infected wounds.
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- Desmoplastic small round cell tumors (DSRCTs) are aggressive tumors linked to a specific chromosome translocation and rarely spread to the brain.
- A 33-year-old man diagnosed with DSRCT in the pelvic area developed unusual symptoms, including a scalp lump and weakness, leading to the discovery of brain metastasis.
- Due to the poor prognosis of DSRCT, aggressive treatment involving surgery, chemotherapy, and radiation is crucial to manage the disease and prevent its progression.
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- Breast cancer is the most prevalent cancer among women globally, and research indicates that larger tumors increase the risk of metastatic disease, prompting an evaluation of breast self-examination (BSE) versus breast awareness.
- The Commission of Senology (CS) of CNGOF utilized established assessment methods to determine the effectiveness of BSE across different groups of women, including general and high-risk populations.
- The findings suggest BSE is not recommended for the general female population, who are encouraged to rely on clinical exams and screenings, while no clear guidelines were established for women over 75 or those with a history of breast cancer due to insufficient data on BSE's benefits for these groups.
Background In the face of the ongoing global health crisis posed by COVID-19, it becomes imperative to understand the disease's dynamics, particularly in specific regions. This study provides a detailed examination of the factors influencing mechanical ventilation (MV) duration among COVID-19 patients in an intensive care setting, focusing on a diverse patient cohort from the Al Hassa region of Saudi Arabia. The primary aim of this study was to identify key demographic factors, clinical outcomes, and comorbidities that affect the duration of MV among ICU patients with COVID-19.
View Article and Find Full Text PDFBackground Breastfeeding and complementary feeding are essential for baby health and nutrition. Concerning these feeding habits, there is a dearth of information on mother awareness and behaviors in Saudi Arabia. This study intends to evaluate maternal knowledge of breastfeeding and complementary feeding in Al Baha City, Saudi Arabia.
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- NAFLD is a growing health concern with no specific FDA-approved treatments currently available.
- A search of ClinicalTrials.gov identified 31 eligible interventional studies, with 19 selected for detailed evaluation, primarily from Korea and China.
- Medications like metformin, Exenatide, and Pioglitazone were among the most studied interventions, highlighting the need for continued research into effective treatments for NAFLD.
Purpose: This study aims to assess contact lens usage patterns, complications, knowledge levels, and the impact of psychological factors on misuse among the Saudi population.
Methods: In this study, we distributed our questionnaire through multiple social media platforms among patients who are using cosmetic or medical contact lenses regardless of the purpose of wearing them. A total of 1,708 contact lens users participated.
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- Only one enzyme from family GH119, the α-amylase from Bacillus circulans, has been experimentally studied, highlighting the need for further research on this enzyme family.
- This study characterizes five enzymes from GH119, all of which are specific to α-amylase but produce different product profiles, indicating diversity within the family.
- The research provides the first kinetic constants for GH119 enzymes and validates previously predicted catalytic residues, suggesting that GH119 and GH57 should be classified together in a new clan (GH-T) in the CAZy database.
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- Alzheimer's disease (AD) is a complex neurodegenerative condition leading to cognitive decline, personality changes, and behavioral issues, making it difficult to treat due to the activation of toxic brain pathways.
- Current treatments have limited effectiveness and often cause side effects, highlighting the potential of early intervention to slow disease progression.
- Curcumin, a natural compound with anti-inflammatory and antioxidant properties, shows promise for AD treatment by protecting brain cells and may work through epigenetic mechanisms, warranting further research into its therapeutic benefits.