Publications by authors named "AlGhamdi H"

Background: Mental illness affects an estimated 25% of the global population, with treatment gaps persisting worldwide. The COVID-19 pandemic has exacerbated these challenges, leading to a significant increase in mental health issues globally. In Saudi Arabia, the lifetime prevalence of mental disorders is estimated at 34.

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Increasing evidence indicates that skin disorders may contribute to an increased risk of autism spectrum disorder (ASD). They can affect the quality of life, and they have an impact on social isolation, behavioral problems, cognitive scores, and some subscales of ASD. This study was an online questionnaire-based, observational, and cross-sectional study conducted during the period from August 2022 through January 2023 to examine dermatological manifestations among ASD individuals compared to controls.

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Background: Cancer is a significant global health issue due to its high incidence and mortality rates. In recent years, the relationship between the human microbiota and cancer has garnered attention across various medical fields. This includes research into the microbial communities that influence cancer development, tumor-associated microorganisms, and the interactions between the microbiome and tumor, collectively referred to as the oncobiome.

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is a highly multidrug-resistant pathogen resistant to almost all classes of antibiotics; new therapeutic strategies against this infectious agent are urgently needed. Shikimate kinase is an enzyme belonging to the shikimate pathway and has become a potential target for drug development. This work describes the search for Food and Drug Administration (FDA)-approved drugs and natural compounds, including gallic acid, that could be repurposed as selective shikimate kinase inhibitors by integrated computational and experimental approaches.

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  • Barium fluoride borosilicate glass samples, reinforced with varying amounts of GdO, were created to study their structural, physical, and optical properties as well as their ability to attenuate γ-rays.
  • X-ray diffraction confirmed the glasses were amorphous, and did show slight increases in density and molar volume with more GdO.
  • UV-Vis spectra indicated increased absorbance and shifts in optical properties, suggesting that these materials could be useful for opto-electronic devices and radiation shielding.
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This report describes the case of a 9-year-old boy with a single ventricular pathway land complex cardiac issue. After multiple cardiac procedures, including a non-fenestrated Fontan shunt at the age of 5 years, the patient presented 2 years later with a recurrent history of cough with whitish, thick and rubbery sputum and shortness of breath and was eventually diagnosed with PB. The patient was treated with medical therapy and failed; at this time, ligation of the thoracic duct was performed, which was a life-saving intervention for him.

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Rhinoplasty and lip lift surgeries are pivotal procedures in facial aesthetics, addressing nose and lip enhancements, respectively. The concurrent execution of these surgeries has gained popularity for achieving improved facial balance and harmony. However, data on the outcomes of combined rhinoplasty and lip lift procedures remain limited.

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  • - The study investigates changes in glycosylated hemoglobin (HbA1c) levels and the risk of post-transplant diabetes mellitus (PTDM) in kidney transplant recipients within the first year, focusing on demographic and health factors.
  • - Results show that 64.04% of the 203 kidney transplant recipients experienced clinically significant HbA1c changes, with pre-transplant diabetes patients showing the most notable increases; PTDM developed in 15.7% of nondiabetics.
  • - Key risk factors for significant HbA1c changes included increased age, weight change, and pre-existing hypertension, while PTDM was linked to older age and higher HbA1c levels at various checkpoints post-transplant
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Introduction: Anaphylaxis is a severe allergic reaction marked by a sudden onset of symptoms affecting multiple bodily systems, and if not addressed promptly, it can lead to fatal outcomes. The primary clinical manifestations often involve skin rash, respiratory distress, and cardiovascular symptoms. Identifying these signs early is crucial for timely intervention, including the administration of epinephrine, aiming to prevent loss of life.

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Background: Eye diseases such as cataracts and glaucoma significantly contribute to vision impairment and blindness worldwide. While cataracts are the leading cause of preventable blindness, glaucoma, often referred to as the "silent thief of sight", can lead to irreversible vision loss if untreated. Despite their prevalence, awareness and understanding of these conditions remain low, particularly in regions like Saudi Arabia, where demographic changes and rising diabetes rates exacerbate the burden of eye diseases.

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Background: Eye diseases, particularly diabetic retinopathy, cataracts, and glaucoma, are significant public health challenges globally, affecting quality of life. Diabetic retinopathy, a common diabetes complication, is a leading cause of visual impairment among working-age adults due to chronic hyperglycemia. Despite treatment advances, awareness of this condition remains low, especially in high-risk populations.

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Demand response-based load scheduling in smart power grids is currently one of the most important topics in energy optimization. There are several benefits to utility companies and their customers from this strategy. The main goal of this work is to employ a load scheduling controller (LSC) to model and solve the scheduling issue for household appliances.

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The generation of municipal solid waste is projected to increase from 2.1 billion tonnes in 2023 to 3.8 billion tonnes by 2050.

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  • - This study explored how enzymes from the marine bacterium Bacillus ligniniphilus L1 can break down natural and synthetic estrogen compounds, using both computational modeling and lab experiments to assess their effectiveness.
  • - Laccase from L1 demonstrated better degradation rates for compounds like estrone and estradiol valerate compared to commercial laccase, particularly when combined with the ABTS enhancer.
  • - Impressively, the L1 catalase-peroxidase outperformed commercial versions in degrading various estrogen compounds, showing significant potential for practical environmental cleanup applications while supporting experimental data through molecular dynamics simulations.
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Dental implants have become the most effective treatment option for replacing missing teeth, worldwide. The popularity and demand for dental implants are continually increasing. Nevertheless, its complications are undeniable.

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Water is a fundamental resource, yet various contaminants increasingly threaten its quality, necessitating effective remediation strategies. Sustainable polymeric adsorbents have emerged as promising materials in adsorption-based water remediation technologies, particularly for the removal of contaminants and deactivation of water-borne pathogens. Pathogenetic water contamination, which involves the presence of harmful bacteria, viruses, and other microorganisms, poses a significant threat to public health.

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  • Rheumatic fever (RF), an autoimmune condition following untreated strep throat, mainly impacts children and can lead to serious heart issues, highlighting the need for awareness and prevention, especially in low-resource areas.
  • A study in Al-Baha, Saudi Arabia, surveyed 415 parents using an online questionnaire to evaluate their knowledge, attitudes, and practices regarding RF and RHD, revealing that most participants had poor knowledge and negative attitudes toward RF.
  • Results showed that only around 4.8% had good knowledge of RF, while 69.2% demonstrated good practices; females were more likely to have better practices than males, suggesting a need for enhanced educational initiatives by health authorities to improve understanding and prevention of these
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Intensive care unit (ICU) e-referrals are an important indicator for exploring potential deficiencies in critical care resources. This study aimed to examine the epidemiology and patterns of ICU e-referrals across all regions of Saudi Arabia during the COVID-19 pandemic using routinely collected data from April 2020 to December 2021. This descriptive epidemiological study analyzed data from the Saudi Medical Appointments and Referrals Centre (SMARC).

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  • - Restructuring the energy industry for sustainability involves moving from carbon-based energy to renewable sources, emphasizing hydrogen as a clean energy carrier, despite challenges related to its transportation and storage due to its high reactivity and low density.
  • - Liquid organic hydrogen carriers (LOHCs) provide a practical solution for hydrogen storage, and the review discusses various technologies and catalyst materials to improve hydrogenation and dehydrogenation processes with examples like benzene/cyclohexane and toluene/methylcyclohexane.
  • - The review also examines the global implementation of a hydrogen economy, focusing on plans in Saudi Arabia and GCC countries, while highlighting challenges such as enhancing hydrogen capacity, reducing energy consumption, and ensuring material stability.
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  • The study focuses on energy optimization in smart power grids (SPGs) to improve efficiency, sustainability, and cost-effectiveness while addressing challenges posed by the uncertainty of distributed generations (DGs) and loads.
  • It introduces a novel optimization model using a probabilistic method combined with the multi-objective wind-driven optimization (MOWDO) technique, which considers economic, environmental, and comfort factors, while also incorporating a hybrid demand response (HDR) system and battery energy storage systems (BESS) for sustainability.
  • Experimental results demonstrate that this new model outperforms existing methods like the multi-objective bird swarm optimization (MOBSO) in optimizing operational costs, user comfort, and pollution emissions.
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  • The World Health Organization says that about 300 million women in developing countries face health problems related to pregnancy and childbirth.
  • A study in the Al-Baha Region of Saudi Arabia looked at how much pregnant women know about signs that indicate complications during pregnancy.
  • Most women in the study understood signs like bleeding and pain, but some still lacked knowledge and had negative attitudes, showing that there's a need for better education about pregnancy risks.
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Background: Overall, stoma-related morbidity affects a reported 20-38% of pediatric patients. However, determining the true incidence of major stoma-related morbidity is challenging due to limited cohort sizes in existing studies. Thus, the aim of this study was to investigate colostomy related morbidity among children both after stoma formation and stoma closure.

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  • IBS is a common gastrointestinal disorder affecting many, with a study revealing a 45% prevalence among physicians in Jeddah, Saudi Arabia, which can significantly impact their quality of life and work.
  • Younger physicians, males, and non-smokers had higher rates of experiencing IBS symptoms, while those who exercised reported fewer symptoms.
  • Nearly half of the participants missed work due to IBS, emphasizing the need for greater awareness and management of this condition in the healthcare sector.
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