Background: Mental illness affects an estimated 25% of the global population, with treatment gaps persisting worldwide. The COVID-19 pandemic has exacerbated these challenges, leading to a significant increase in mental health issues globally. In Saudi Arabia, the lifetime prevalence of mental disorders is estimated at 34.
View Article and Find Full Text PDFIncreasing evidence indicates that skin disorders may contribute to an increased risk of autism spectrum disorder (ASD). They can affect the quality of life, and they have an impact on social isolation, behavioral problems, cognitive scores, and some subscales of ASD. This study was an online questionnaire-based, observational, and cross-sectional study conducted during the period from August 2022 through January 2023 to examine dermatological manifestations among ASD individuals compared to controls.
View Article and Find Full Text PDFInfect Agent Cancer
January 2025
Background: Cancer is a significant global health issue due to its high incidence and mortality rates. In recent years, the relationship between the human microbiota and cancer has garnered attention across various medical fields. This includes research into the microbial communities that influence cancer development, tumor-associated microorganisms, and the interactions between the microbiome and tumor, collectively referred to as the oncobiome.
View Article and Find Full Text PDFBackground: Sickle cell disease (SCD) is an autosomal recessive genetic blood disorder. It affects up to 2.6% of the Kingdom of Saudi Arabia population.
View Article and Find Full Text PDFis a highly multidrug-resistant pathogen resistant to almost all classes of antibiotics; new therapeutic strategies against this infectious agent are urgently needed. Shikimate kinase is an enzyme belonging to the shikimate pathway and has become a potential target for drug development. This work describes the search for Food and Drug Administration (FDA)-approved drugs and natural compounds, including gallic acid, that could be repurposed as selective shikimate kinase inhibitors by integrated computational and experimental approaches.
View Article and Find Full Text PDFThis report describes the case of a 9-year-old boy with a single ventricular pathway land complex cardiac issue. After multiple cardiac procedures, including a non-fenestrated Fontan shunt at the age of 5 years, the patient presented 2 years later with a recurrent history of cough with whitish, thick and rubbery sputum and shortness of breath and was eventually diagnosed with PB. The patient was treated with medical therapy and failed; at this time, ligation of the thoracic duct was performed, which was a life-saving intervention for him.
View Article and Find Full Text PDFRhinoplasty and lip lift surgeries are pivotal procedures in facial aesthetics, addressing nose and lip enhancements, respectively. The concurrent execution of these surgeries has gained popularity for achieving improved facial balance and harmony. However, data on the outcomes of combined rhinoplasty and lip lift procedures remain limited.
View Article and Find Full Text PDFTher Adv Endocrinol Metab
November 2024
Introduction: Anaphylaxis is a severe allergic reaction marked by a sudden onset of symptoms affecting multiple bodily systems, and if not addressed promptly, it can lead to fatal outcomes. The primary clinical manifestations often involve skin rash, respiratory distress, and cardiovascular symptoms. Identifying these signs early is crucial for timely intervention, including the administration of epinephrine, aiming to prevent loss of life.
View Article and Find Full Text PDFBackground: Eye diseases such as cataracts and glaucoma significantly contribute to vision impairment and blindness worldwide. While cataracts are the leading cause of preventable blindness, glaucoma, often referred to as the "silent thief of sight", can lead to irreversible vision loss if untreated. Despite their prevalence, awareness and understanding of these conditions remain low, particularly in regions like Saudi Arabia, where demographic changes and rising diabetes rates exacerbate the burden of eye diseases.
View Article and Find Full Text PDFBackground: Eye diseases, particularly diabetic retinopathy, cataracts, and glaucoma, are significant public health challenges globally, affecting quality of life. Diabetic retinopathy, a common diabetes complication, is a leading cause of visual impairment among working-age adults due to chronic hyperglycemia. Despite treatment advances, awareness of this condition remains low, especially in high-risk populations.
View Article and Find Full Text PDFDemand response-based load scheduling in smart power grids is currently one of the most important topics in energy optimization. There are several benefits to utility companies and their customers from this strategy. The main goal of this work is to employ a load scheduling controller (LSC) to model and solve the scheduling issue for household appliances.
View Article and Find Full Text PDFThe generation of municipal solid waste is projected to increase from 2.1 billion tonnes in 2023 to 3.8 billion tonnes by 2050.
View Article and Find Full Text PDFDental implants have become the most effective treatment option for replacing missing teeth, worldwide. The popularity and demand for dental implants are continually increasing. Nevertheless, its complications are undeniable.
View Article and Find Full Text PDFWater is a fundamental resource, yet various contaminants increasingly threaten its quality, necessitating effective remediation strategies. Sustainable polymeric adsorbents have emerged as promising materials in adsorption-based water remediation technologies, particularly for the removal of contaminants and deactivation of water-borne pathogens. Pathogenetic water contamination, which involves the presence of harmful bacteria, viruses, and other microorganisms, poses a significant threat to public health.
View Article and Find Full Text PDFIntensive care unit (ICU) e-referrals are an important indicator for exploring potential deficiencies in critical care resources. This study aimed to examine the epidemiology and patterns of ICU e-referrals across all regions of Saudi Arabia during the COVID-19 pandemic using routinely collected data from April 2020 to December 2021. This descriptive epidemiological study analyzed data from the Saudi Medical Appointments and Referrals Centre (SMARC).
View Article and Find Full Text PDFBMC Pediatr
October 2024
Background: Overall, stoma-related morbidity affects a reported 20-38% of pediatric patients. However, determining the true incidence of major stoma-related morbidity is challenging due to limited cohort sizes in existing studies. Thus, the aim of this study was to investigate colostomy related morbidity among children both after stoma formation and stoma closure.
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