Buspirone attenuated methotrexate-induced hippocampal toxicity in rats by regulating Nrf2/HO-1, PPAR-γ, NF-κB/nNOS, and ROS/NLRP3/caspase-1 signaling pathways.

Methotrexate (MTX) is a chemotherapeutic agent widely used to treat a variety of tumors. Nonetheless, MTX-induced hippocampal neurotoxicity is a well-defined dose-limiting adverse effect that limits clinical utility. Proinflammatory cytokine production and oxidative stress are possible mechanisms for MTX-induced neurotoxicity.

Promising hepatoprotective effects of lycopene in different liver diseases.

The incidence of liver diseases such as hepatitis, fibrosis, cirrhosis, and liver cancer is one of the world's most significant health challenges. Liver diseases can be caused by a variety of circumstances, including viral infection, exposure to xenobiotics, environmental pollutants, metabolic disorders, and others. Lycopene (LYC) is a potent antioxidant of the carotenoid family in red fruits and vegetables.

Gender Differences in Smoking Attitude among Saudi Medical Students.

Background: Smoking is a growing public health problem throughout the world. However, the attitude of males and females toward smoking may differ. Therefore, this study examines gender differences in smoking behavior and attitude among Saudi medical students.

Zingerone alleviates the delayed ventricular repolarization and AV conduction in diabetes: Effect on cardiac fibrosis and inflammation.

Background: The study aims to analyse the action of zingerone in diabetes-related cardiac arrhythmias.

Methods: Diabetes was induced by streptozocin while treatment groups received 20 mg/kg zingerone daily. Following extra seven weeks, electrocardiography, extraction of blood, urine and heart for biochemical analysis, histopathology and immunofluorescence were undertaken.