Publications by authors named "Al-Rawashdeh S"

Article Synopsis
  • Cardiovascular diseases, particularly hereditary Long QT Syndrome (LQTS), are linked to ion channel dysfunctions, leading to a higher risk of sudden cardiac death, especially with the LQT2 type caused by mutations in the hERG gene.
  • Specific high-affinity hERG blockers like E-4031 could potentially rescue these dysfunctional channels, but the mechanisms behind their effectiveness are unclear.
  • The study employs accelerated molecular dynamics simulations to show how mutations in the hERG channel alter its structure and trafficking, and suggests that E-4031 may inhibit these detrimental changes, paving the way for new treatments targeting the underlying cellular issues.
View Article and Find Full Text PDF

Background: The World Health Organization recommended the use of chemical-based disinfectants as an effective prevention of the COVID-19 pandemic. However, calls for poisoning were reported in several medical centers. The widespread use of chemical-based disinfectants as a preventive measure during the COVID-19 pandemic has underscored potential gaps in community awareness and performance, posing health risks.

View Article and Find Full Text PDF
Article Synopsis
  • This study investigates the prevalence of illness anxiety disorder (IAD) and stress among medical and nursing students at a Saudi Arabian university, highlighting differences in their anxiety levels and characteristics.
  • Data was collected from 216 medical and 250 nursing students using measurement tools for assessing health anxiety and distress.
  • Results indicated that nursing students displayed a higher prevalence of IAD (57.2%) compared to medical students (17.6%), suggesting a need for enhanced mental health support in both disciplines to mitigate potential impacts on academic performance and future careers.
View Article and Find Full Text PDF

Small colloidally aggregating molecules (SCAMs) can be problematic for biological assays in drug discovery campaigns. However, the self-associating properties of SCAMs have potential applications in drug delivery and analytical biochemistry. Consequently, the ability to predict the aggregation propensity of a small organic molecule is of considerable interest.

View Article and Find Full Text PDF

The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates biological signals to control various complicated cellular functions. It plays a crucial role in environmental sensing and xenobiotic metabolism. Dysregulation of AhR is associated with health concerns, including cancer and immune system disorders.

View Article and Find Full Text PDF

Background: Although breakfast skipping among university students is a significant concern, its prevalence and the contributing factors among university students have received little attention in the literature. This study aims to determine the prevalence of skipping breakfast among Jordanian university students and examine the associated factors and variations in rates of skipping breakfast by day of the week.

Materials And Methods: A cross-sectional study was conducted among undergraduate students between March and May 2022 through a self-questionnaire.

View Article and Find Full Text PDF

Purpose: This study examined the Jordanian registered nurses' perceptions of the obstacles and supportive behaviors of End-of-Life Care in Intensive Care Units and examined the differences in the concepts based on the samples' demographics.

Methods: A cross-sectional and comparative study was conducted using a convenience sample of 230 Intensive Care Unit registered nurses in Jordan. Data were analyzed descriptively, and differences were measured using the independent sample t-test, the one-way Analysis of Variance, and Scheffe's post hoc test.

View Article and Find Full Text PDF

In the current drug development process, molecular dynamics (MD) simulations have proven to be very useful. This chapter provides an overview of the current applications of MD simulations in drug discovery, from detecting protein druggable sites and validating drug docking outcomes to exploring protein conformations and investigating the influence of mutations on its structure and functions. In addition, this chapter emphasizes various strategies to improve the conformational sampling efficiency in molecular dynamics simulations.

View Article and Find Full Text PDF

Objective: Competency denotes the ability to execute a certain task or action with the necessary knowledge. Competency definitions and measurements are challenging for nursing and other professions due to their multidimensional aspects. This study aimed to clarify the concept of competency in nursing practice and propose an accurate definition.

View Article and Find Full Text PDF

Background: Authentic leadership controls quality care and the safety of patients and healthcare professionals, especially nurses.

Aim: This study examined the influence of nurses' authentic leadership on the safety climate.

Methods: In this predictive research, 314 Jordanian nurses from various hospitals were convenience sampled for cross-sectional and correlational design.

View Article and Find Full Text PDF

The repolarizing current (I) produced by the hERG potassium channel forms a major component of the cardiac action potential and blocking this current by small molecule drugs can lead to life-threatening cardiotoxicity. Understanding the mechanisms of drug-mediated hERG inhibition is essential to develop a second generation of safe drugs, with minimal cardiotoxic effects. Although various computational tools and drug design guidelines have been developed to avoid binding of drugs to the hERG pore domain, there are many other aspects that are still open for investigation.

View Article and Find Full Text PDF

To examine critical care nurses' perceived barriers and enablers of pain assessment and management. This descriptive correlational study recruited a convenience sample of 200 Jordanian nurses. Pain Assessment and Management for the Critically Ill questionnaire was used to measure the study variables.

View Article and Find Full Text PDF

Background: Anxiety is a predictor of a bad prognosis in patients with coronary heart disease. Patients with coronary heart disease undergoing percutaneous coronary intervention (PCI) reported high levels of anxiety, yet little is known about changes in anxiety levels after this procedure.

Objective: The aim of this study was to examine changes in anxiety levels of patients undergoing PCI and identify differences in anxiety levels based on patients' demographics and clinical details.

View Article and Find Full Text PDF

Repetitive online searches for health information increase anxieties and result in Internet addiction. Internet addiction, cyberchondria, anxiety sensitivity, and hypochondria have been studied separately, but how these concepts are reciprocally linked has not been investigated. This study aimed to determine the levels, correlations, and predictors of Internet addiction, cyberchondria, anxiety sensitivity, and hypochondria among students based on the sample's characteristics.

View Article and Find Full Text PDF

Purpose: The aim of this study is to describe our experience in laparoscopic partial nephrectomy and to compare the differences between off-clamp and on-clamp techniques in terms of clinical characteristics and outcomes.

Methods: A retrospective study was utilized. A purposeful sampling method was used to select the patients.

View Article and Find Full Text PDF

Tinnitus is a well-known pathological entity in clinical practice. However, the pathophysiological mechanisms behind tinnitus seem to be elusive and cannot provide a comprehensive understanding of its pathogenesis and clinical manifestations. Hence, in the present study, we explore the mathematical model of ions' quantum tunneling to propose an original pathophysiological mechanism for the sensation of tinnitus.

View Article and Find Full Text PDF

Purpose: This study aims to compare nurses' authentic leadership and perceptions of the safety climate and concepts association according to different areas of work and types of hospitals.

Design/methodology/approach: A cross-sectional design was used to conduct this comparative study on 314 Jordanian nurses. The Authentic Leadership Questionnaire (ALQ) and the Safety Climate Survey (SCS) were used.

View Article and Find Full Text PDF
Article Synopsis
  • * A total of 209 NHRs were examined, revealing that those without cognitive impairment, those with higher anticholinergic burden scores, and those taking more oral pills daily used more analgesics.
  • * The results aim to enhance understanding of analgesic prevalence and factors, which can help improve pain management practices and guidelines in nursing homes, particularly in Jordan.
View Article and Find Full Text PDF

Background: Previous literature has investigated the association of this phenomenon and Internet addiction. Nevertheless, little research has been conducted to elucidate the predictive associations among these concepts among students.

Objective: This study reported students' cyberchondria and Internet addiction, and it examined whether cyberchondria predicts Internet addiction.

View Article and Find Full Text PDF

Background: People around the world look hesitant to get the coronavirus disease-2019 (COVID-19) vaccine. Identifying factors behind people's hesitancy is of great importance.

Aim: This paper aimed at examining the predictors of the intention to get the COVID-19 vaccine in a sample of 281 Jordanians.

View Article and Find Full Text PDF

Recently, the COVID-19 pandemic has triggered different behaviors in education, especially during the lockdown, to contain the virus outbreak in the world. As a result, educational institutions worldwide are currently using online learning platforms to maintain their education presence. This research paper introduces and examines a dataset, E-LearningDJUST, that represents a sample of the student's study progress during the pandemic at Jordan University of Science and Technology (JUST).

View Article and Find Full Text PDF

Despite the effectiveness of cognitive behavior therapy (CBT) in relieving death anxiety and ageism among nurses, there is not a complete consensus on its acceptability, adherence, credibility, and expectancy in the literature. Therefore, this descriptive-comparative study aimed to examine Jordanian nurses' perception of using CBT in relieving death anxiety and ageism. Most participants perceived CBT as a credible and adherable treatment for death anxiety and ageism.

View Article and Find Full Text PDF

Background: Medication errors are detrimental to patient safety and the quality of hospital services.

Purpose: The purpose of the study was to compare registered nurses working in the small-, medium-, and large-sized Jordanian hospitals' responses in terms of reported rate and cause of medication errors and their views on medication error reporting.

Methods: This was a cross-sectional comparative design, with a total sample of 229 nurses working in different-sized hospitals.

View Article and Find Full Text PDF

Objectives: The current study aimed to examine nurses' critical thinking and decision-making skills related to pain management and their association with nurses' characteristics.

Research Methodology/design: This descriptive correlational study used a convenience sample of 115 critical care nurses working in a university hospital in Jordan. Data were collected using a pain-related vignette and validated questionnaires.

View Article and Find Full Text PDF

Background: Hope is important for patients with end-stage renal disease receiving haemodialysis (HD) and hope is associated with quality of life (QoL). Studies examining hope among the HD population are limited and, as far as the authors know, have not been undertaken in Jordan.

Aims: To examine levels of hope and QoL and to examine the association between hope and QoL in HD patients in Jordan.

View Article and Find Full Text PDF