Assessment of Preparedness for Sport Injuries by Primary School Teachers: A Nation-Wide Survey in Saudi Arabia.

Background: This study aimed to assess the level of readiness among primary school teachers to handle sports injuries in Saudi Arabia.

Methods:  A structured questionnaire was applied to collect information on teachers, training, knowledge, attitudes, and perceived barriers in managing common sports injuries. Descriptive analysis was performed for demographics and baseline information.

Physical and mechanical characterizations of experimental pit and fissure sealants based on bioactive glasses.

Fissure sealants commonly exhibit weak mechanical and physical properties, potentially compromising their effectiveness in preventing dental caries. Therefore, this laboratory study aimed to synthesize and characterize experimental pit and fissure sealants in comparison with a commercially available sealant. Three different formulations of experimental pit and fissure sealing materials were synthesized using a blend of bisphenol A-glycidyl methacrylate (Bis-GMA) and triethylene glycol dimethacrylate (TEGDMA) monomers.

Synthesis and Evaluation of Thiazolyl-indole-2-carboxamide Derivatives as Potent Multitarget Anticancer Agents.

Cancer is a complex disease driven by the dysregulation of multiple signaling pathways and cellular processes. The development of compounds capable of exerting multitarget actions against these key pathways involved in cancer progression is a promising therapeutic approach. Here, a series of novel (/)--(4-(2-(2-(substituted)hydrazineyl)-2-oxoethyl)thiazol-2-yl)-1-indole-2-carboxamide derivatives (-) were designed, synthesized, and evaluated for their biological activity.

Microbial Changes in the Periodontal Environment Due to Orthodontic Appliances: A Review.

Orthodontic appliances significantly influence the microbiological dynamics within the oral cavity, transforming symbiotic relationships into dysbiotic states that can lead to periodontal diseases. This review synthesizes current findings on how orthodontic treatments, particularly fixed and removable appliances, foster niches for bacterial accumulation and complicate oral hygiene maintenance. Advanced culture-independent methods were employed to identify shifts toward anaerobic and pathogenic bacteria, with fixed appliances showing a more pronounced impact compared to clear aligners.

Noninvasive Ventilation in Critically Ill Patients With Severe Acute Respiratory Infections.

Background: The objective of this study was to evaluate the association between noninvasive ventilation (NIV) compared with invasive ventilation and mortality in subjects with severe acute respiratory infection.

Methods: This was a retrospective multi-center study of subjects with severe acute respiratory infection treated with ventilatory support between September 2012 and June 2018. We compared the 90-d mortality of subjects managed initially with NIV (NIV group) with those managed with invasive ventilation only (invasive ventilation group), adjusting by propensity score.

Synthesis, Cytotoxicity, and Photophysical Investigations of 2-Amino-4,6-diphenylnicotinonitriles: An Experimental and Theoretical Study.

In this study, we present a comprehensive investigation of 2-amino-4,6-diphenylnicotinonitriles (APNs, -), including their synthesis, cytotoxicity against breast cancer cell lines, and photophysical properties. Compound demonstrates exceptional cytotoxicity, surpassing the potency of Doxorubicin. The fluorescence spectra of the synthesized - in different solvents reveal solvent-dependent shifts in the emission maximum values, highlighting the influence of the solvent environment on their fluorescence properties.

Evaluation of Clinical Preventive Management Provided by Primary Healthcare Physicians Against Brucellosis in Saudi Arabia.

Background:  Brucellosis is among the most common zoonotic bacterial infections, leading to major public health consequences in endemic areas such as Saudi Arabia. Primary healthcare is crucial in controlling brucellosis, as it serves as the frontline for disease prevention, early detection, and appropriate management. However, enhancing the contribution of primary healthcare to the entire brucellosis notification process is necessary to minimize the underreporting and inadequate data collection, which hinders the implementation of effective control measures.

Cam-type hip morphology in asymptomatic patients.

Background: The alpha angle has been widely used in the assessment of cam-type of impingement, but recent studies have shown that this angle may also be high in asymptomatic patients. The aim of this study is to report the prevalence of cam-type morphology in asymptomatic volunteers and explore its correlation with hip clinical and radiological parameters.

Methods: This single-centre prospective study included 48 asymptomatic male volunteers (96 hips).

Adoption of on-farm feed safety practices among livestock farmers: Evidence from Saudi Arabia.

Compliance with feed safety standards and practices on the farm promotes sustainable livestock production and can positively affect the environment and human health. This study aims to examine farmers' on-farm adoption of feed safety practices and determine the differences in adoption according to the socio-economic characteristics of farmers. An online survey was conducted to collect the study data.

Electronic cigarette vapor disrupts key metabolic pathways in human lung epithelial cells.

The steady increase in the use of electronic cigarettes (ECs) has reached an epidemic level, increasing mortality and morbidity, mainly due to pulmonary toxicity. Several mechanisms are involved in EC-induced toxicity, including oxidative stress and increased inflammation. Concurrently, the integrity of cellular metabolism is essential for cellular homeostasis and mitigation of toxic insults.

Revisiting the radiation of on the Arabian Peninsula and testing the suitability of captive breeding stock for reintroduction, using mitochondrial and nuclear markers.

Today, the Arabian gazelle () occurs only in small, scattered populations on the Arabian Peninsula and is classified as 'vulnerable', due to intensive hunting and competition with livestock. The taxonomy of this threatened species is still under debate, hampering conservation efforts while ex-situ breeding programs could be an appropriate conservation measure to prevent the species from going extinct. In our study, we attempted to elucidate the radiation of on the Arabian Peninsula, and to ask whether the population genetic structure allows to distinguish between discrete conservation units.

A Rare Case of Multifocal Cystadenomatous Oncocytic Hyperplasia of the Parotid Gland.

Multifocal cystadenomatous oncocytic hyperplasia of the parotid gland is an extremely rare non-neoplastic lesion. We present a case involving a 73-year-old female with a painless, small mass in her right preauricular region for the past two months. Fine needle aspiration suggested a diagnosis of mucoepidermoid carcinoma.

Assessment of 5% Amlexanox, 0.1% Triamcinolone Acetonide and 0.03% Tacrolimus in the Management of Oral Lichen Planus.

Objectives: Compare 5% amlexanox, 0.1% triamcinolone acetonide, and 0.03% tacrolimus in the management of oral lichen planus (OLP).

The Outcome of Congenital Cardiac Surgery in Patients with Down Syndrome: Single-Center Experience.

Objectives: This study aimed to describe the outcomes of Down syndrome patients who underwent cardiac surgery for congenital heart defects and to develop risk prediction models for in-hospital mortality, recurrent hospital admission, and the need for catheter intervention among a cohort of patients.

Methods: This single-centre retrospective cohort study included consecutive Down syndrome patients who underwent cardiac surgery for congenital heart defects between January 2018 and December 2021. We reviewed the electronic medical records.

A new distribution record of Arnold's Gecko, (Arnold, 1977) (Squamata, Sphaerodactylidae), in Saudi Arabia.

Reptiles are considered an important element of Saudi Arabia's wildlife to be conserved as a priority. However, the status and distribution of the Kingdom's reptile fauna is not well understood, thus hindering the conservation initiatives. Better understanding of the taxonomy and distribution of the Kingdom's reptile fauna is important for implementing effective conservation measures.

Characterisation of engineered titanium dioxide nanoparticles in selected food.

Titanium dioxide (TiO), an E171 manufacturer-made food additive, is extensively utilised as a colourant in drug and a food products. Some studies showed that most of confectionary and food items contain inexplicable particles. The aim of this article is to determine the size and structure of TiO nanoparticles in different food products.

The effect of various washing methods on pesticide residues, toxic and essential elements removal in rice.

This study examined the effects of various treatments on removing pesticide residues and toxic elements in rice. In parallel, nutritional elements, magnesium (Mg), potassium (K), and phosphorous (P), were measured to investigate the effect of these washing treatments on the nutritional value of rice. A naturally contaminated rice sample containing five widespread used pesticides (azoxystrobin, buprofezin, carbendazim, and propiconazole) and toxic elements, arsenic (As), cadmium (Cd), and essential elements, was washed using several washing agents, including boiling water, 5% sodium bicarbonate (baking soda), 5% acetic acid (vinegar), 5% citric acid, and 5% sodium chloride (salt).

A Facile Synthesis and Molecular Characterization of Certain New Anti-Proliferative Indole-Based Chemical Entities.

Cancer cells frequently develop drug resistance, which leads to chemotherapeutic treatment failure. Additionally, chemotherapies are hindered by their high toxicity. Therefore, the development of new chemotherapeutic drugs with improved clinical outcomes and low toxicity is a major priority.

Impact of a national collaborative project to improve the care of mechanically ventilated patients.

This prospective quasi-experimental study from the NASAM (National Approach to Standardize and Improve Mechanical Ventilation) collaborative assessed the impact of evidence-based practices including subglottic suctioning, daily assessment for spontaneous awakening trial (SAT), spontaneous breathing trial (SBT), head of bed elevation, and avoidance of neuromuscular blockers unless otherwise indicated. The study outcomes included VAE (primary) and intensive care unit (ICU) mortality. Changes in daily care process measures and outcomes were evaluated using repeated measures mixed modeling.