Vanillin and IGF1-loaded dual-layer multifunctional wound dressing with micro-nanofibrous structure for full-thickness wound healing acceleration.

Multifunctional dual-layer wound dressings hold significant promise for comprehensive full-thickness wound management by closely mimicking the native skin structure and features. Herein, we employed an innovative approach utilizing electrospinning techniques to develop a dual-layer dressing comprising a microfibrous Ecoflex®-Vanillin (Ex-Vnil) top layer (TL) and a nanofibrous Soluplus®-Insulin-like growth factor-1 (Sol-IGF1) bottom layer (BL). The tensile properties of dual-layer wound dressings were within the standard range for use in skin tissue regeneration.

Physicochemically Cross-linked Injectable Hydrogel: an Adhesive Skin Substitute for Burned Wound Therapy.

Burns carry a large surface area, varying in shapes and depths, and an elevated risk of infection. Regardless of the underlying etiology, burns pose significant medical challenges and a high mortality rate. Given the limitations of current therapies, tissue-engineering-based treatments for burns are inevitable.

Antibacterial and wound healing stimulant nanofibrous dressing consisting of soluplus and soy protein isolate loaded with mupirocin.

Severe cutaneous injuries may not heal spontaneously and may necessitate the use of supplementary therapeutic methods. Electrospun nanofibers possess high porosity and specific surface area, which provide the necessary microenvironment for wound healing. Here in, the nanofibers of Soluplus-soy protein isolate (Sol-SPI) containing mupirocin (Mp) were fabricated via electrospinning for wound treatment.

Vasculo-osteogenic keratin-based nanofibers containing merwinite nanoparticles and sildenafil for bone tissue regeneration.

Vascularization of bone tissue constructs plays a pivotal role in facilitating nutrient transport and metabolic waste removal during the processes of osteogenesis and bone regeneration in vivo. In this study, a sildenafil (Sil)-loaded nanofibrous scaffold of keratin/Soluplus/merwinite (KS.Me.

Comparative study of using the Neodymium-doped yttrium Aluminium Garnet laser alone or in combination with the High Intensity Focussed Ultrasound technique for removing the professional tattoo.

Objective: To evaluate the effects of combining neodymium-doped yttrium aluminium garnet laser and highintensity focussed ultrasound techniques to remove a professionally-done tattoo.

Methods: The interventional study was conducted from November 2021 to April 2022 at the at the Postgraduate Medical Physics Laboratory of Mustansiriyah University, Baghdad, Iraq, and comprised healthy adults aged 18-60 years who wished to have their tattoo areas from their hands, arms and forearms removed. Each tattoo was divided into 3 areas.

In vitro comparison of low-power diode pumping solid-state laser radiation at 589 and 650 nm on red blood cells suspension viscosity, stability, and deformability.

Objective: To investigate the effect of diode-pumped solid-state laser irradiation with yellow 589nm and red 650nm wavelengths on rheological parameters in vitro.

Methods: The comparative study was conducted between November 2021 and April 2022 at the at the Postgraduate Medical Physics Laboratory, Mustansiriyah University, Baghdad, Iraq, and comprised blood samples from healthy adult volunteers. The samples were divided into 4 aliquots.

The correlation of the modulation complexity score (MCS) with the number of segments and local gamma passing rate for the Intensity Modulated Radiation Therapy (IMRT) treatment planning delivery.

Objective: To compare the modulation complexity scores across treatment sites, and to examine their connection with monitor unit, segment number and global and local gamma passing percentage.

Methods: The cross-sectional study was conducted at the Baghdad Centre for Radiation Therapy and Nuclear Medicine, Baghdad Medical City, Baghdad, Iraq, from May 2021 to February 2022. Included were 34 patients, with the age range between 20 - 50 years, subjected to intensity-modulated radiation therapy for head and neck tumours in group A or pelvic tumours in group B.

A comparative study of 589 and 532 nm low level laser irradiation effects on normal human peripheral blood mononuclear cells viability.

Objective: To assess how laser light affects blood lymphocyte viability in vitro.

Methods: The comparative study was conducted from November 2021 to April 2022 at the Department of Medical Physics, Mustansiriyah University, Baghdad, Iraq, and comprised blood samples collected from healthy adults with no medical history of major illnesses or history of taking medications for major diseases.Low-level laser 589nm and 532nm was used at 30 J/cm², 50 J/cm² and 70J/cm² energy intensities and three different post-exposure time; immediately, 1h and 2h after radiation exposure.

The effect of a diode-pumped solid-state laser with a wavelength of 589 nm on T-lymphocyte proliferation.

Objective: To assess how low-level laser irradiation affects T cells.

Methods: The case-control interventional study was conducted from November 2021 to April 2022 after approval by the ethics review committee of the College of Medicine, Mustansiriyah University, Baghdad, Iraq, and comprised healthy individuals. Phlebotomy was used to collect 4ml of blood.

A Comparative study between the efficacy of combined Intense Pulsed Light plus high-intensity focussed ultrasound in the treatment of atrophic and icepick scars.

Objective: To investigate the efficiency of high-intensity focussed ultrasound with intense pulsed light in the treatment of atrophic and icepick acne scars.

Methods: The interventional study was conducted between November 2021 and April 2022 at the Postgraduate Medical Physics Laboratory, Mustansiriyah University, Baghdad, Iraq, and comprised patients with atrophic scars in group A and acne scars in group B. They were treated first with intense pulsed light and then with high-intensity focussed ultrasound.

Evaluation of the effect of yellow laser (DPSS) light on human lymphocytes viability in vitro.

Objective: To evaluate the lymphocyte apoptotic impact of yellow laser light in vitro.

Methods: The experimental study was conducted from November 2021 to April 2022 at the Postgraduate Medical Physics Laboratory, Mustansiriyah University, Baghdad, Iraq, and comprised blood samples from healthy volunteers. The samples were subjected to 1:1 dilution in isotonic phosphate buffered saline, and each sample was divided into two equal aliquots; one for irradiation, and other as control.

Effect of 532nm and 589nm Diode-Pumped Solid-State (DPSS) Lasers with Different Doses on Concentration of Total Protein and Albumin in Vitro.

Objective: To test the effects of Low-level laser irradiation at 532nm and 589nm with different doses and exposure times on total protein and albumin in blood plasma.

Methods: This experimental study was conducted from November 2021 to April 2022 at Mustansiriyah University, Baghdad, Iraq, and comprised blood samples from healthy adults. The samples were stored in tubes containing anticoagulant ethylenediaminetetraacetic acid.

A comparison study of 589 and 650 nm on improving stored whole blood stability by irradiation with a low-power diode pumping solid-state laser.

Objective: To assess the effects of diode-pumped solid-state laser irradiation with 589nm and 650nm wavelengths on the stability of stored red blood cells in vitro.

Methods: This is an intervention study that was conducted from April to July 2021 at the Physiology and Medical Physics Laboratory, College of Medicine, Mustansiriyah University, Baghdad, Iraq, and comprised samples of healthy, adult human blood that were put in tubes with citrate-phosphate dextrose-adenine as an anticoagulant. The blood sample was divided into eight equal aliquots and stored for 21 days at 4ºC.

Three-dimensional printed polyelectrolyte construct containing mupirocin-loaded quaternized chitosan nanoparticles for skin repair.

Despite substantial advancements in wound dressing development, effective skin repair remains a significant challenge, largely due to the persistent issue of recurrent infections. Three-dimensional printed constructs that integrate bioactive and antibacterial agents hold significant potential to address this challenge. In this study, a 3D-printed hydrogel scaffold composed of polyallylamine hydrochloride (PAH) and pectin (Pc), incorporated with mupirocin (Mp)-loaded quaternized chitosan nanoparticles (QC NPs) was fabricated.

Early-onset renal dysfunction in Jeune syndrome: A case report with atypical presentation.

Jeune syndrome, a rare autosomal recessive disorder, is characterized by skeletal abnormalities, particularly a narrow, bell-shaped chest, leading to severe respiratory distress in newborns. This case report details a full-term female neonate presenting with significant respiratory challenges, typical skeletal features, and early-onset renal dysfunction. Despite normal initial imaging, persistent renal abnormalities were observed, underscoring the need for early diagnosis, vigilant monitoring, and a multidisciplinary management approach to optimize outcomes for patients with Jeune syndrome.

Tannic acid-reinforced soy protein/oxidized tragacanth gum-based multifunctional hemostatic film for regulation of wound healing.

With recent advances in the field of tissue engineering, composite films with biocompatibility, antimicrobial properties, and wound healing properties have gained potential applications in the field of wound dressings. In this research work, composite films of soy protein (S)/oxidized tragacanth gum (G) were successfully made using the solution casting process. The metal-organic framework containing curcumin (MOF) with concentrations of 5 and 10 wt% and tannic acid (TA) with concentrations of 6 and 12 wt% were entered into the polymer film.