Bacterial dysbiosis in newly diagnosed treatment naïve pediatric ulcerative colitis in Saudi Arabia.

Background: The role of microbiota in the pathogenesis of ulcerative colitis (UC) has been increasingly recognized. However, most of the reports are from Western populations. In Middle Eastern countries, including Saudi Arabia, little is known about the role of microbiota.

Microbiota profile of new-onset celiac disease in children in Saudi Arabia.

Background: Intestinal dysbiosis has been reported to be associated with celiac disease (CeD) in Western populations but little is known in other populations who have different dietary lifestyle and genetic background. The purpose of this study was to determine whether a different microbiota profile is associated with CeD in children in Saudi Arabia.

Results: Forty children with CeD, 20 healthy controls, and 19 non-CeD controls were enrolled.

Fungal Dysbiosis in Children with Celiac Disease.

Background: Although intestinal fungi are known to interact with the immune system, the relationship between intestinal fungi and childhood celiac disease (CeD), an immune-mediated condition, has rarely been reported.

Aims: The aim of this study was to describe gut fungal profiles in a cohort of children with new-onset CeD.

Methods: Mucosal and fecal samples were collected from children with CeD and controls and subjected to metagenomics analysis of fungal microbiota communities.

Diagnostic delay of pediatric inflammatory bowel disease in Saudi Arabia.

Background/aim: Delay in the diagnosis of inflammatory bowel disease (IBD) is associated with complications. Our aim was to describe the pattern and risk factors associated with delay in the diagnosis of IBD in Saudi children.

Patients And Methods: This was a multicenter study with a retrospective/prospective design.

Microbiota profile in new-onset pediatric Crohn's disease: data from a non-Western population.

Background: The role of microbiota in Crohn's disease (CD) is increasingly recognized. However, most of the reports are from Western populations. Considering the possible variation from other populations, the aim of this study was to describe the microbiota profile in children with CD in Saudi Arabia, a non-Western developing country population.

Pre-illness diet as risk factor in pediatric inflammatory bowel disease in Saudi Arabia.

Background/aim: Inflammatory bowel disease (IBD) is increasing in Saudi Arabia but there's little knowledge about its risk factors. Our aim is to investigate the dietary risk factors of this disease in Saudi children.

Patients And Methods: The children investigated for IBD were prospectively enrolled.

Impact of pediatric inflammatory bowel disease on linear growth: Data from a national cohort study in Saudi Arabia.

Background/aim: Linear growth impairment (LGI) is one of the most important features peculiar to children with inflammatory bowel disease (IBD). The aim of this report is to define the impact of IBD on the linear growth of children in the Kingdom of Saudi Arabia (KSA).

Setting And Design: Multicenter retrospective study.

Characteristics of Pediatric Crohn's Disease in Saudi Children: A Multicenter National Study.

Background and Aims. Crohn's disease (CD) is an evolving disease in KSA. Little is known about its characteristics in the Saudi population.

Nutritional status of children with inflammatory bowel disease in Saudi Arabia.

Aim: To assess the prevalence of nutritional disorders in children with inflammatory bowel disease (IBD) in Saudi Arabia.

Methods: The data from a national cohort of children newly diagnosed with IBD between 2003 and 2012 were analyzed. The diagnosis of IBD and the differentiation between Crohn's disease (CD) and ulcerative colitis (UC) were confirmed by gastroenterologists according to the standard criteria.

Incidence of pediatric inflammatory bowel disease in Saudi Arabia: a multicenter national study.

Background: Pediatric inflammatory bowel disease (IBD) is increasingly recognized in developing countries; however, the incidence and trend over time have not been reported.

Methods: This retrospective study included children diagnosed with IBD in gastroenterology centers in the Kingdom of Saudi Arabia between 2003 and 2012. The date of birth, date and age at diagnosis, gender, and final diagnosis were collected on special forms.

Emerging inflammatory bowel disease in saudi outpatients: a report of 693 cases.

Background/aim: Inflammatory bowel disease (IBD) is a chronic disease of unknown etiology and considered traditionally as a disease of the western world. Recently, rising trends have been observed in countries previously known to have a low prevalence and incidence. The aim of this study is to collect epidemiological data on IBD outpatients and to add data from the Kingdom of Saudi Arabia (KSA) to the available IBD literature.

Consanguinity and inflammatory bowel diseases: is there a relation?

Objective: The aim of the present study was to investigate the relation between consanguinity and inflammatory bowel diseases (IBD).

Methods: Review of the medical records of children with a final diagnosis of IBD to determine age, sex, and type of IBD, supplemented by information on consanguinity and family history (FH) of IBD in relatives. There were 138 children, ages 1.

Presenting features of childhood-onset inflammatory bowel disease in the central region of Saudi Arabia.

Objective: To investigate the presenting features of childhood-onset inflammatory bowel disease (IBD) in the central region of Riyadh, Saudi Arabia and to compare with those reported in the literature.

Methods: This is a retrospective review of medical records of children below 18 years of age at onset of symptoms with confirmed diagnosis of IBD for age, gender, family history, presenting clinical and laboratory findings in the Divisions of Pediatric and Adult Gastroenterology, King Khalid University Hospital (which provides free health care) and the Department of Gastroenterology Al Mofarreh Poly Clinic, Riyadh, Saudi Arabia, between January 1993 and December 2010.

Results: Two hundred and eighteen children diagnosed with IBD with predominance of males in Crohn's disease (CD) (56%) and females in ulcerative colitis (UC) (59%).

Crohn's disease in a Saudi outpatient population: is it still rare?

Background/aim: To determine the epidemiology of Crohn's disease (CD) in an outpatient clinic and compare it with data previously reported from different centers in the Kingdom of Saudi Arabia and outside.

Materials And Methods: The medical records of all patients with CD seen in the clinic in the period from January 1993 through December 2007 were reviewed. The demographic, clinical data and methods of diagnosis were retrieved.

Esophageal ulceration complicating doxycycline therapy.

Aim: To report present state of iatrogenic drug-induced esophageal injury (DIEI) induced by medications in a private clinic.

Methods: Iatrogenic drug-induced esophageal injury (DIEI) induced by medications has been more frequently reported. In a private clinic we encountered 36 cases of esophageal ulcerations complicating doxycycline therapy in a mainly younger Saudi population (median age 29 years).

Gammaglutamyl transpeptidase activity in patients with schistosomiasis.

Background: Schistosoma mansoni infestation may induce liver fibrosis and portal hypertension, with possible elevation of liver enzymes.

Aim Of The Study: The aim of this study was to evaluate the serum gammaglutamyl transpeptidase (GGT) activity in a group of non-alcoholic and non-obese patients with hepatointestinal schistosomiasis.

Patients And Methods: Medical records of 174 patients diagnosed to have hepatointestinal schistosomiasis on the basis of clinical and laboratory data were reviewed.

Formol-ether concentration method in the diagnosis of active schistosoma mansoni in patients with detectable IHA.

Schistosomiasis is a world wide human infection. In Saudi Arabia there are multiple endemic foci. Various methods have been used to diagnose Schistosoma mansoni.

Esophageal candidiasis among a dyspeptic population.

This is a retrospective study of 59 patients endoscoped over a period of six years at a private clinic and were found to have esophageal candidiasis. The median age was 46.38 years.

Doxycline-induced esophageal ulcerations.

Over a period of six years 16 patients presented to Dr. Al Mofarreh's polyclinic with drug--induced esophageal ulcerations. One patient had esophagitis without ulcerations and two patients, who declined endoscopy were not included in this analyzis.

The role of ERCP in the management of gallstone-associated acute pancreatitis: A prospective study of 64 patients at Riyadh Central Hospital.

In a prospective study, consecutive patients admitted to one of the surgical units at Riyadh Central Hospital with a diagnosis of acute biliary pancreatitis (ABP) underwent, after stabilization, urgent ERCP within 72 hours of admission. A total of 64 patients (35 males, 29 females) were treated over a four-year period (1986-1990). Forty-eight patients were found to have common bile duct stones when endoscopic sphincterotomy (ES) and stone extraction was performed, including four patients with concomitant cholangitis.

Primary sclerosing cholangitis in chronic ulcerative colitis: report of cases in Arabs and review.

Primary sclerosing cholangitis (PSC), a chronic cholestatic liver disease, is increasingly recognized in association with chronic ulcerative colitis (CUC). Two cases of PSC were diagnosed among 78 Arab patients (2.7%) with CUC followed up at Riyadh Central Hospital.