Critical Evaluation of Combined Cu and FeO Nanodots with Gum Arabic Nano-Hybrids Using in-vitro Model: Flow Cytometry and Cell Viability Studies.

Background: Previous studies on synthesis and cytotoxicity effect of copper (Cu) and magnetite (FeO) nanodots against kidney and lung cancer cells Lines.

Purpose: Investigation of the effects of Cu and FeO nanodots on the reduction in viability of lung cancer (A549) and human embryonic kidney (HEK239T) cells lines.

Methods: Cu and FeO nanodots/Gum Arabic (GA) hybrids were chemically synthesized, characterized, and assessed by MTT and flow cytometry for their cytotoxicity against A549 and HEK239T cells lines.

A Green analytical method for simultaneous determination of dexamethasone sodium phosphate and prednisolone acetate in veterinary formulations using UV spectroscopy and dimension reduction algorithms.

Precise determination of veterinary pharmaceutical concentrations represents a critical foundation for delivering safe and efficacious animal healthcare interventions. Two synthetic glucocorticoids - dexamethasone sodium phosphate (DXM) and prednisolone acetate (PRD) - are extensively employed in veterinary medicine due to their potent anti-inflammatory capabilities. Our research presents a novel, cost-effective, and environmentally sustainable analytical methodology that enables simultaneous quantification of DXM and PRD within binary veterinary formulations.

The impact of study habits and personal factors on the academic achievement performances of medical students.

Background: Academic achievement is essential for all students seeking a successful career. Studying habits and routines is crucial in achieving such an ultimate goal.

Objectives: This study investigates the association between study habits, personal factors, and academic achievement, aiming to identify factors that distinguish academically successful medical students.

Antibacterial composite films of oxidized alginate-chitosan-ZnO anchored Cu nanoparticles for the degradation of organic pollutants.

The growing population and urbanization have adversely affected the environment including water. The waste water from industries has affected not only human but also animals. The availability of clean water is one of the foremost needs for living organism.

Expression of CD6 in Aggressive NK/T-cell Neoplasms and Assessment as a Potential Therapeutic Target: A Bone Marrow Pathology Group Study.

Background: Aggressive NK/T-Cell neoplasms are rare hematological malignancies characterized by the abnormal proliferation of NK or NK-like T (NK/T) cells. CD6 is a transmembrane signal transducing receptor involved in lymphocyte activation and differentiation. This study aimed to investigate the CD6 expression in these malignancies and explore the potential of targeting CD6 in these diseases.

Synthesis of oxidized carboxymethyl cellulose-chitosan and its composite films with SiC and SiC@SiO nanoparticles for methylene blue dye adsorption.

The cationic methylene blue (MB) dye sequestration was studied by using oxidized carboxymethyl cellulose-chitosan (OCMC-CS) and its composite films with silicon carbide (OCMC-CS-SiC), and silica-coated SiC nanoparticles (OCMC-CS-SiC@SiO). The resulting composite films were characterized through various analytical techniques, including Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Thermogravimetric analysis (TGA), Field emission scanning electron microscopy (FESEM), and energy-dispersive X-ray spectroscopy (EDS). The dye adsorption properties of the synthesized composite films were comprehensively investigated in batch experiments and the effect of parameters such as contact time, initial dye concentration, catalyst dosages, temperature, and pH were systematically evaluated.

Correction: Hybridized sulfated-carboxymethyl cellulose/MWNT nanocomposite as highly selective electrochemical probe for trace detection of arsenic in real environmental samples.

[This corrects the article DOI: 10.1039/D3RA03808D.].

Hybridized sulfated-carboxymethyl cellulose/MWNT nanocomposite as highly selective electrochemical probe for trace detection of arsenic in real environmental samples.

A highly selective and ultra-sensitive electrochemical sensing probe was proposed by combining sulfated-carboxymethyl cellulose (CMC-S) and a functionalized-multiwalled carbon nanotube (f-MWNT) nano-composite with high conductivity and durability. The CMC-S/MWNT nanocomposite was impregnated on a glassy carbon electrode (GCE) to construct the non-enzymatic and mediator-free electrochemical sensing probe for trace detection of As(iii) ions. The fabricated CMC-S/MWNT nanocomposite was characterized by FTIR, SEM, TEM, and XPS.

A Ganglion Cyst in the Anterior Cruciate Ligament of a 13-Year-Old Boy.

Intra-articular ganglion cysts of the knee are a rare occurrence in pediatric patients, particularly involving the anterior cruciate ligament (ACL). Only a handful of case reports have been documented in the medical literature, highlighting the rarity of this condition. Patients with intra-articular cysts often experience knee discomfort and mechanical symptoms like locking of the knee.

Biologically active sulfur-containing polyamides as promising anticancer materials.

Thiazol-based molecules have practically infinite biological implementation. Today, there are many medical applications for compounds containing the thiazole moiety owing to their presence in most clinically applied anticancer drugs, such as dasatinib, dabrafenib, ixabepilone, patellamide A and epothilone. In this study, the polycondensation, of a new group of thiazole-containing polyamides with the formulas PA was carried out by the interaction of 2-aminothiazole diphenyl sulfide and variable diacid chlorides in dimethyl formamide in the presence of potassium carbonate anhydrous as a catalyst.

Triple-Negative Primary Myelofibrosis: A Bone Marrow Pathology Group Study.

Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm driven by canonical gene mutations in JAK2, CALR, or MPL in >80% of the cases. PMF that lacks these canonical alterations is termed triple-negative PMF (TN-PMF). The pathologic and genetic characteristics of TN-PMF compared with those of conventional PMF with canonical driver mutations (DM-PMF) have not been well studied.

Chemical modification of microcrystalline cellulose with polyethyleneimine and hydrazine: Characterization and evaluation of its adsorption power toward anionic dyes.

Functionalization and various applications of biomaterials have progressively gained a major interest due to the cost-effectiveness, renewability, and biodegradability of these substrates. The current work focalized on the functionalization of microcrystalline cellulose with polyethyleneimine solution (3 %, 5 %, and 10 %) and hydrazine sulfate salt (1:1, 1:2, 2:1) using an impregnation method. Untreated and treated samples were characterized using FT-IR, SEM, XRD, TGA, and DTA analyses.

Synthesis of New Cobalt(III) -Porphyrin Complex, Photochemical, X-ray Diffraction, and Electrical Properties for Photovoltaic Cells.

The present work describes the preparation and characterization of a new cobalt(III) porphyrin coordination compound named (chlorido)(nicotinoylchloride)[-tetra(-chlorophenyl)porphyrinato]cobalt(III) dichloromethane monosolvate with the formula [Co(TClPP)Cl(NTC)]·CHCl (). The single-crystal X-ray molecular structure of shows very important ruffling and waving distortions of the porphyrin macrocycle. The Soret and Q absorption bands of are very red-shifted as a consequence of the very distorted porphyrin core.

Novel thiazole derivatives incorporating phenyl sulphonyl moiety as potent BRAFV600E kinase inhibitors targeting melanoma.

Novel thiazole derivatives possessing phenyl sulfonyl moiety were designed and synthesized as B-RAFV600E kinase inhibitors based on the clinically-approved anticancer drug, dabrafenib. All target compounds showed significant inhibition of B-RAFV600E kinase enzyme at nanomolar levels. Compounds 7b and 13a revealed excellent B-RAFV600E inhibitory activity, superior to that of dabrafenib with IC values of 36.

A bioresource catalyst system of alginate-starch-activated carbon microsphere templated Cu nanoparticles: Potentials in nitroarenes hydrogenation and dyes discoloration.

The evolution and development of solid-matrix are considered a backbone for supporting and stabilizing of metal nanoparticles (NPs) and are the soul of the catalytic system. In the current study, the alginate-starch microsphere (Alg-St) was cross-linked using CaCl as a cross-linker. In addition, the Alg-St microsphere was blended with different percentages of activated carbon (AC).

Chitosan-CdS Quantum Dots Biohybrid for Highly Selective Interaction with Copper(II) Ions.

Cadmium sulfide (CdS) quantum dots (QDs) were homogeneously embedded into chitosan (CTS), denoted as CdS@CTS, via an in situ hydrothermal method. The intact structure of the synthesized materials was preserved using freeze-drying. The materials were characterized using X-ray diffraction (XRD), X-ray photoelectron spectroscopy, transmission electron microscopy, high-resolution TEM, scanning TEM, dispersive energy X-ray (EDX) for elemental analysis and mapping, Fourier transform infrared spectroscopy, nitrogen adsorption-desorption isotherms, thermogravimetric analysis, UV-vis spectroscopy, and diffuse reflectance spectroscopy (DRS).

Versatility of Hydrogels: From Synthetic Strategies, Classification, and Properties to Biomedical Applications.

Hydrogels are three-dimensional, cross-linked, and supramolecular networks that can absorb significant volumes of water. Hydrogels are one of the most promising biomaterials in the biological and biomedical fields, thanks to their hydrophilic properties, biocompatibility, and wide therapeutic potential. Owing to their nontoxic nature and safe use, they are widely accepted for various biomedical applications such as wound dressing, controlled drug delivery, bone regeneration, tissue engineering, biosensors, and artificial contact lenses.

Revealing the Effect of MnO, Activated Carbon and MnO/Activated Carbon on Chitosan Polymer Host Fabricated Co NPs: Antibacterial Performance and Degradation of Organic Compounds.

MnO and MnO blended with 1 and 2 weight percent of activated carbon (AC), MnO/AC1 and MnO/AC2 were synthesized through the sol-gel method. The pure chitosan (CS) films were cast in the form of films. Similarly, 5 weight% of each MnO, AC, MnO/AC1 and MnO/AC2 was intermingled with the CS to produce different films, such as CS-AC, CS-MnO, CS-MnO/AC1 and CS-MnO/AC2.

Synthesis of copper oxide nanoparticles using leaves and decolorization studies.

In this investigation, leaves were used as a promising source of bioproducts for the reduction of copper sulfate into copper oxide nanoparticles. The prepared nanoparticles were characterized using Fourier-transform infrared spectroscopy (FT-IR), X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission electron microscopy (TEM), and Thermogravimetric analysis (TGA). FI-IR showed the presence of hydroxyl, ester, and aromatic groups, which are characteristics of phenolics and other bioproducts.

Referral Time of Advance Cancer Patients to Palliative Care Services and Its Predictors in Specialized Cancer Center.

Background and aim Globally, there is a discrepancy in whether terminal cancer patients are early referred to palliative care service (PCS) or not. A late referral can lead to a delay in treating and palliating those patients in need. The aim of this study is to investigate the referral time patterns of advanced cancer patients to PCS in Princess Noorah Oncology Center (PNOC) at King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia.

Adsorption, kinetics and thermodynamics studies of methyl orange dye sequestration through chitosan composites films.

Different films comprising pure chitosan (CS) and chitosan coated sodium zeolites composites films designated as CSZ1, CSZ2, CSZ3 and CSZ4 respectively are presented here for the sequestration of MO dye. The as-synthesized films were characterized by using FSESM, XPS XRD, and TGA analysis. The sequestration of methyl orange dye (MO) was studied under various adsorption parameters i.

A Cellulosic Fruit Derived from Biomaterial: Chemical Characterization and Its Valuable Use in the Biosorption of Methylene Blue in a Batch Mode.

Cellulose substrate waste has demonstrated great potential as a biosorbent of pollutants from contaminated water. In this study, fruit, an agricultural waste biomaterial, was used for the biosorption of methylene blue from synthetic solution. Fourier-transform infrared (FTIR) spectroscopy indicated the presence of the main absorption peak characteristics of cellulose, hemicellulose, and lignin compositions.

A microscopic and macroscopic investigation of the adsorption of N719 dye on ZnO nanopowders (ZNP) and ZnO nanorods (ZNR) for dye sensitized solar cells using statistical physics treatment and DFT simulation.

In this paper, three adsorption isotherms of N719 dye on two different adsorbents, ZnO nanopowder and ZnO nanorods, at three different thicknesses have been fitted using a monolayer model with three types of receptor sites treated by statistical physics. The model involved parameters are: three coefficients ( , and ) indicating the numbers of adsorbed dye molecules per site, three parameters ( , and ) indicating the receptor site densities and three adsorption energies ((- ), (- ) and (- )). The evolution of these parameters in relation with thickness of ZnO was discussed.

An Acetylcholinesterase Inhibition-Based Biosensor for Aflatoxin B Detection Using Sodium Alginate as an Immobilization Matrix.

In this study, we investigated a novel aflatoxin biosensor based on acetylcholinesterase (AChE) inhibition by aflatoxin B1 (AFB1) and developed electrochemical biosensors based on a sodium alginate biopolymer as a new matrix for acetylcholinesterase immobilization. Electrochemical impedance spectroscopy was performed as a convenient transduction method to evaluate the AChE activity through the oxidation of the metabolic product, thiocholine. Satisfactory analytical performances in terms of high sensitivity, good repeatability, and long-term storage stability were obtained with a linear dynamic range from 0.