Invasive sino-orbital aspergillosis with brain invasion in an immunocompetent pregnant patient.

Purpose: Invasive Fungal Sinusitis (IFS) is a potentially life-threatening condition that can progress rapidly to the orbit and the brain, especially if it goes on undetected for a long period. We report a case of a 28-year-old pregnant woman in her second trimester with sino-orbital and subsequent brain involvement who tragically developed deterioration of her neurological status and a spontaneous abortion.

Observations: The patient presented to the ophthalmology emergency department, King Khaled Eye Specialist Hospital, Riyadh, complaining of left upper eyelid fullness with a palpable eyelid mass and chronic relapsing remitting dull pain for 4 months.

Eyelid molluscum contagiosum presenting as a giant solitary ulcerating mass.

Molluscum contagiosum is a benign viral cutaneous infection. It typically presents as an asymptomatic centrally umbilicated nodule 3-5 mm in diameter. Susceptible patients are children and adults receiving immunosuppressive therapy.

Bioequivalence and pharmacokinetics of chlorpheneramine in healthy human volunteers.

This study was carried out to evaluate the bioavailability of a new regular release tablet formulation of chlorphenamine (CPA) (Histop) relative to a reference formula (Piriton) using 13 human healthy volunteers. Each one received the two formulations as two 4 mg tablets in a two-way double-blind, crossover study. The concentration of CPA was measured with a sensitive high performance liquid chromatography (HPLC).