Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib.

Background: Loss of heterozygosity (LOH) diminishes genetic diversity within cancer genomes. A tumour arising in an individual heterozygous for a functional and a loss-of-function (LoF) allele of a gene occasionally retain only the LoF allele. This can result in deficiency of specific protein activities in cancer cells, creating unique differences between tumour cells and normal cells of the individual.

Modelling terrigenous DOC across the north west European Shelf: Fate of riverine input and impact on air-sea CO fluxes.

Terrigenous carbon in aquatic systems is increasingly recognised as an important part of the global carbon cycle. Despite this, the fate and distribution of terrigenous dissolved organic carbon (tDOC) in coastal and oceanic systems is poorly understood. We have implemented a theoretical framework for the degradation of tDOC across the land to ocean continuum in a 3D hydrodynamical-biogeochemical model on the North West European Shelf.

Ultraviolet-activated clamshell hydroxyapatite-substituted palladium in the photoreduction of methyl orange water pollutant.

This study focuses on the modification of natural hydroxyapatite (HAp) derived from clamshell by impregnation with palladium (Pd) at different pH in wet precipitation method to produce photoactive green materials for the degradation of synthetic dyes. It was found that, at pH 10, Pd has been successfully impregnated into HAp lattice with Ca/P ratio of 1.77 and particle distribution size range of 40-470 nm.

Effects of polymorphism of and genes on the chemical composition of meat in cull female cattle.

Aim: This study aimed to investigate the association of single nucleotide polymorphism of the () and () genes on the total water, ash, fat, protein, and cholesterol contents of sirloin ( muscle) and silverside ( muscle) meats of cull female cattle.

Materials And Methods: This analysis covered a total of 27 cull female cattle slaughtered at the Animal Slaughterhouse of Banda Aceh that was purposively selected based on hair color referred to the criteria described in the Decree of Ministry of Agriculture of the Republic of Indonesia. Genomic DNA was extracted from 25 mg of fresh meat using the spin column method before subjected to a polymerase chain reaction amplification using primer sets specific for 1346-bp and 275-bp fragments of and , respectively.

Analysis of bloom conditions in fall 2013 in the Strait of Hormuz using satellite observations and model simulations.

In this study an algal bloom event in fall 2013 in the Strait of Hormuz was thoroughly investigated using satellite remote sensing and hydrodynamic modeling. The motivation of this study is to deduce ambient conditions prior to and during the bloom outbreak and understand its trigger. Bloom tracking was achieved by sequential MODIS imagery and numerical simulations.

Functional Outcome With Percutaneous Ilio-sacral Screw Fixation For Posterior Pelvic Ring Injuries In Patients Involved In Heavy Manual Laboring.

Introduction: Unstable posterior pelvic ring injuries are best treated with operative methods due to better post-op functional score. Our patient cohort was involved in heavy manual laboring frequently required ground level work in their activities of daily living. There are very few outcome studies dealing exclusively with such patients.

Biotin biosynthesis in Mycobacterium tuberculosis: physiology, biochemistry and molecular intervention.

Biotin is an important micronutrient that serves as an essential enzyme cofactor. Bacteria obtain biotin either through de novo synthesis or by active uptake from exogenous sources. Mycobacteria are unusual amongst bacteria in that their primary source of biotin is through de novo synthesis.