Pachyphyllanone, a new cycloartane triterpenoid isolated from and its cytotoxic activity.

is a species from the genus (Meliaceae) and the chemical constituent has not been widely explored. A new cycloartane-type triterpenoid, pachyphyllanone (), along with four known compounds (-) were isolated from Miq. Furthermore, the structure of the new compound was elucidated by the interpretation of spectroscopic data, including 1D and 2D-NMR, as well as ECD and NMR calculations (DP4+ analysis).

Immunomodulatory of sesquiterpenoids and sesquiterpenoid dimers-based toll-like receptor 4 (TLR4) from Dysoxylum parasiticum stem bark.

In recent decades, the interest in natural products with immunomodulatory properties has increased due to their therapeutic potential. These products have a wider range of pharmacological activities and demonstrate lower toxicity levels when compared to their synthetic counterparts. Therefore, this study aimed to investigate the immunomodulatory effects of sesquiterpenoids (SQs) and sesquiterpenoid dimers (SQDs) isolated from Dysoxylum parasiticum (Osbeck) Kosterm.

Alliaxylines A-E: five new mexicanolides from the stem barks of Dysoxylum alliaceum (Blume) Blume ex A.Juss.

A total of five new mexicanolides (1-5), namely alliaxylines A-E, together with two known limonoids 6 and 7, were isolated and identified from Dysoxylum alliaceum (Blume) Blume ex. A.Juss.

Excelxylin A: a new A-ring tirucallane triterpenoid from the stem bark of .

A new -A tirucallane triterpenoid named excelxylin A (), along with two known -A triterpenoids (), were isolated from the -hexane extract of (Spreng.) Blume ex G.Don stem bark.

Paraxylines A-G: Highly oxygenated preurianin-type limonoids with immunomodulatory TLR4 and cytotoxic activities from the stem bark of Dysoxylum parasiticum.

Seven previously undescribed preurianin-type limonoids, namely paraxylines A-G, and three known analogs were isolated from stem bark of Dysoxylum parasiticum. The structures, including absolute configurations, were established through spectroscopic analyses, quantum chemical calculations using the density functional theory method, as well as the DP4+ algorithm. Paraxylines A-G were identified as the first preurianin-type with full substitution at C, D-rings, leading to the highly oxygenated seco-limonoids skeleton.

Sesquiterpenoids from Meliaceae Family and Their Biological Activities.

Sesquiterpenoids, an important class of natural products possessing three isoprene-derived units, are widely distributed across plants and have a variety of biological activities. All sesquiterpenoids are derived from farnesyl pyrophosphate (FPP), a biosynthesis precursor that can form various carbon skeletons. In order to provide a reference for further research and development of these compounds, this review focused on the increasing number of isolated and volatile sesquiterpenoids found to be produced by plants of the Meliaceae family between 1968 and 2023.

New steroid produced by K5 isolated from (Meliaceae) and its heme polymerization inhibition activity.

A new ergostane-type steroid named (22)-3α,6α,9α-ergosta-7,22-diene-3,6,9-triol (), along with six known steroids 5α,8α-epidioxy-24-ethyl-cholest-6-en-3β-ol (), ergosterol-5,8-peroxide (), cerevisterol (), isocyathisterol (), 6β-hydroxystigmast-4-en-3-one (), 6β-hydroxy-4-campesten-3-one (), were isolated from the fermented unpolished rice media by K5 (Periconiaceae), an endophytic fungus from medicinal plant (Meliaceae). The fermentation takes at 28 ± 2 °C for 30 days. The structure of new steroid ( was elucidated by extensive spectroscopic measurements (IR, HR-ESI-TOFMS, and 1D and 2D NMR) analyses.

Dysoticans F-H: three unprecedented dimeric cadinanes from (Osbeck) Kosterm. stem bark.

An asymmetrical true-dimeric cadinane ketonic bridge [C-15/C-3'], dysotican F (1), two symmetrical pseudo-cadinane dimers through an -ether linkage [C-3/C-3'], dysoticans G (2) and H (3), as well as three known sesquiterpenoids 4-6 were obtained from the stem bark of (Osbeck) Kosterm. (Meliaceae). Their structures were determined by spectroscopic and quantum chemical calculations of C NMR shifts using a GIAO method and electronic circular dichroism (ECD) using a TDDFT method.

New Triterpenoids from Corr. cv and Their Cytotoxic Activity.

Corr. is a member of the Meliaceae family that is widely spread in tropical and subtropical region of Asia and America. Traditionally, the fruit of this plant has been consumed because of its sweet taste.

Tirucallane-type triterpenoid from the stem bark of and its cytotoxic activity against MCF-7 breast cancer cells.

Chisocarpene A () is a new tirucallane-type triterpenoid together with odoratone () and 24-methylenecycloartanol (), isolated from the stem bark of . The chemical structures of compounds were elucidated through a detailed analysis of their spectroscopic data (IR, MS, 1 D, and 2 D NMR). The isolated compounds were evaluated for cytotoxic activity against the MCF-7 breast cancer cell line using a resazurin-based assay.

Triterpenoids from Dysoxylum genus and their biological activities.

This study aims to analyze the ethnobotanical, chemical, and biological activities of triterpenoid compounds isolated from the Dysoxylum genus of the Meliaceae family between 1974 and 2021. The species are mainly distributed in Africa, Asia, and Australia, and used as a traditional medicine to treat various diseases. Triterpenoid was first isolated in 1976 and as tetranortriterpenoid or limonoid, it was named dysobinin.